Search by BoMiProt ID - Bomi216

Primary Information

BoMiProt ID Bomi216
Protein Name Annexin A4
Organism Bos taurus
Uniprot IDP13214
Milk FractionMFGM, Exosome
Ref Sequence ID NP_001001440.2
Aminoacid Length 319
Molecular Weight 35889
FASTA Sequence Download
Gene Name ANXA4
Gene ID 281625
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondary Information

Protein Function inhibit the Cl channel through a direct protein-protein interaction; part of a complex signaling pathway involving both protein kinases and intracellular Ca2 +; involved in a direct molecular interplay with the Ca2 -dependent Cl channel
Biochemical Properties Annexins IV were found in the nuclear fraction; Annexin IV from cytosolic and nuclear fractions had similar molecular masses and isoelectric points with mean pI of 7.0 and 7.3 respectively
PTMs phosphorylated by protein kinase C
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
SCOP Class : All alpha proteins
Fold : Annexin
Superfamily : Annexin
Family : Annexin
Domain Name : 1I4A A:10-318

CATH Matched CATH superfamily
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1. Nilius, B., Gerke, V., Prenen, J., Szücs, G., Heinke, S., Weber, K., & Droogmans, G. (1996). Annexin II modulates volume-activated chloride currents in vascular endothelial cells. The Journal of Biological Chemistry, 271(48), 30631–30636.
2. Katoh, N., Suzuki, T., Yuasa, A., & Miyamoto, T. (1995). Distribution of annexins I, II, and IV in bovine mammary gland. Journal of Dairy Science, 78(11), 2382–2387.