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Primary Information | |
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| BoMiProt ID | Bomi216 |
| Protein Name | Annexin A4 |
| Organism | Bos taurus |
| Uniprot ID | P13214 |
| Milk Fraction | MFGM, Exosome |
| Ref Sequence ID | NP_001001440.2 |
| Aminoacid Length | 319 |
| Molecular Weight | 35889 |
| FASTA Sequence | Download |
| Gene Name | ANXA4 |
| Gene ID | 281625 |
| Protein Existence Status | Reviewed: Experimental evidence at protein level |
Secondary Information | |
| Protein Function | inhibit the Cl channel through a direct protein-protein interaction; part of a complex signaling pathway involving both protein kinases and intracellular Ca2 +; involved in a direct molecular interplay with the Ca2 -dependent Cl channel |
| Biochemical Properties | Annexins IV were found in the nuclear fraction; Annexin IV from cytosolic and nuclear fractions had similar molecular masses and isoelectric points with mean pI of 7.0 and 7.3 respectively |
| PTMs | phosphorylated by protein kinase C |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | |
| SCOP | Class : All alpha proteins Fold : Annexin Superfamily : Annexin Family : Annexin Domain Name : 1I4A A:10-318 |
| CATH | Matched CATH superfamily 1.10.220.10 |
| Predicted Disorder Regions | NA |
| DisProt Annotation | |
| TM Helix Prediction | No TM helices |
| PDB ID | 1ANN, 1AOW, 1I4A, |
| Bibliography | 1. Nilius, B., Gerke, V., Prenen, J., Szücs, G., Heinke, S., Weber, K., & Droogmans, G. (1996). Annexin II modulates volume-activated chloride currents in vascular endothelial cells. The Journal of Biological Chemistry, 271(48), 30631–30636. https://doi.org/10.1074/jbc.271.48.30631. 2. Katoh, N., Suzuki, T., Yuasa, A., & Miyamoto, T. (1995). Distribution of annexins I, II, and IV in bovine mammary gland. Journal of Dairy Science, 78(11), 2382–2387. https://doi.org/10.3168/jds.S0022-0302(95)76866-7. |