Search by BoMiProt ID - Bomi214

Primary Information

BoMiProt ID Bomi214
Protein Name Cytosol aminopeptidase
Organism Bos taurus
Uniprot IDP00727
Milk FractionExosome
Ref Sequence ID NP_776523.2
Aminoacid Length 519
Molecular Weight 56289
FASTA Sequence Download
Gene Name LAP3
Gene ID 781648
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondary Information

Protein Function catalyze the rapid hydrolysis of aminoacyl-/3-naphthylamides. Leucine aminopeptidase (LAP, EC: is an important metalloexopeptidase that catalyze the hydrolysis of amino-terminal leucine residues from polypeptides and proteins.
Biochemical Properties broader specificity while hydrolyzing Leu substrates; have variable temperature and pH optima and divalent cation requirements;
Significance in milk show high potential in removing the bitterness of milk by hydrolysis of polypeptides
PTMs N6-acetyllysine,Phosphorylation at Serine
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
SCOP Class : Alpha and beta proteins (a/b)
Fold : Phosphorylase/hydrolase-like
Superfamily : Zn-dependent exopeptidases
Family : Leucine aminopeptidase, C-terminal domain
Domain Name : 1LAM A:160-484

Class : Alpha and beta proteins
Fold : Macro domain-like
Superfamily : Macro domain-like
Family : PepA N-terminal domain-like
Domain Name : 1LAM A:1-159

CATH Matched CATH superfamily
Predicted Disorder Regions 48-51
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1. TALANTI, S., & HOPSU, V. K. (1961). Leucine aminopeptidase in the mammary gland of the cow and rat. Nature, 191, 86–87.
2. Jóźwik, A., Bagnicka, E., Śliwa-Jóźwik, A., Strzałkowska, N., Sloniewski, K., Krzyżewski, J., & Kolataj, A. (2004). Activity of selected aminopeptidases of whole milk in cows as related to feeding season (autumn/winter vs spring/summer)..
3. Starnes, W. L., & Behal, F. J. (1974). A human liver aminopeptidase. The amino acid and carbohydrate content, and some physical properties of a sialic acid containing glycoprotein. Biochemistry, 13(16), 3221–3227. 4.Zhang S, Cai X, Luo X, Wang S, Guo A, Hou J, Wu R. Molecular cloning and characterization of leucine aminopeptidase gene from Taenia pisiformis. Exp Parasitol. 2018 Mar;186:1-9. doi: 10.1016/j.exppara.2018.01.012. Epub 2018 Jan 10. PMID: 29329981.