Primary Information
BoMiProt ID	Bomi212
Protein Name	4-trimethylaminobutyraldehyde dehydrogenase
Organism	Bos taurus
Uniprot ID	Q2KJH9
Milk Fraction	Exosome
Ref Sequence ID	NP_001039888.1
Aminoacid Length	494
Molecular Weight	53977
FASTA Sequence	Download
Gene Name	ALDH9A1
Gene ID	537539
Protein Existence Status	Reviewed: Experimental evidence at transcript level
Secondary Information
Protein Function	cytosolic NAD1-dependent aldehyde dehydrogenase; converts γ-trimethylaminobutyraldehyde into g-butyrobetaine; trimethyllysine released upon protein degradation is oxidized to γ-butyrobetaine (BB) by the action of trimethyllysine dioxygenase (TMLHE), 3-hydroxy-N-TML aldolase and 4-N-trimethylaminobutyraldehyde dehydrogenase
Significance in milk	mRNA abundances of 4-N-trimethylaminobutyraldehyde dehydrogenase is increased in liver biopsy samples of cows in late pregnancy and early lactation
PTMs	N6-Acetylation at Lys and Ser
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation
Predicted Disorder Regions	(232-255)
DisProt Annotation
TM Helix Prediction	No TM helices
Bibliography	1. Schlegel, G., Keller, J., Hirche, F., Geissler, S., Schwarz, F. J., Ringseis, R., … Eder, K. (2012). Expression of genes involved in hepatic carnitine synthesis and uptake in dairy cows in the transition period and at different stages of lactation. BMC Veterinary Research, 8, 28. https://doi.org/10.1186/1746-6148-8-28. 2. Vaz, F. M., Fouchier, S. W., Ofman, R., Sommer, M., & Wanders, R. J. (2000). Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis. The Journal of Biological Chemistry, 275(10), 7390–7394. https://doi.org/10.1074/jbc.275.10.7390.