Search by BoMiProt ID - Bomi21

Primary Information

BoMiProt ID Bomi21
Protein Name Actin, alpha skeletal muscle
Organism Bos taurus
Uniprot IDP68138
Milk FractionWhey
Ref Sequence ID NP_776650.1
Aminoacid Length 377
Molecular Weight 42051
FASTA Sequence Download
Gene Name ACTA1
Gene ID 281592
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondary Information

Protein Function maintenance of the cytoskeleton, cell motility and muscle contraction
Biochemical Properties Skeletal and cardiac mammalian actin isoforms differ slightly from each other at 4 side chains where substitutions Glu2Asp, Asp3Glu, Leu299Met, and Thr358Ser convert skeletal to cardiac actin; In normal adult humans, skeletal muscle is homogeneous in the skeletal -actin
Significance in milk Cytoskeletal proteins; found increased during infection
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Linking IDs
Bibliography 1. Belyantseva, I. A., Perrin, B. J., Sonnemann, K. J., Zhu, M., Stepanyan, R., McGee, J., … Ervasti, J. M. (2009). γ-Actin is required for cytoskeletal maintenance but not development. Proceedings of the National Academy of Sciences of the United States of America, 106(24), 9703–9708. https://doi.org/10.1073/pnas.0900221106.
2. VANDEKERCKHOVE, J., & WEBER, K. (1979). The Complete Amino Acid Sequence of Actins from Bovine Aorta, Bovine Heart, Bovine Fast Skeletal Muscle, and Rabbit, Slow Skeletal Muscle: A Protein-Chemical Analysis of Muscle Actin Differentiation. Differentiation, 14(1–3), 123–133. https://doi.org/10.1111/j.1432-0436.1979.tb01021.
2. VANDEKERCKHOVE, J., & WEBER, K. (1979). The Complete Amino Acid Sequence of Actins from Bovine Aorta, Bovine Heart, Bovine Fast Skeletal Muscle, and Rabbit, Slow Skeletal Muscle: A Protein-Chemical Analysis of Muscle Actin Differentiation. Differentiation, 14(1–3), 123–133. https://doi.org/10.1111/j.1432-0436.1979.tb01021.
3. Addis, M. F., Pisanu, S., Marogna, G., Cubeddu, T., Pagnozzi, D., Cacciotto, C., … Uzzau, S. (2013). Production and release of antimicrobial and immune defense proteins by mammary epithelial cells following Streptococcus uberis infection of sheep. Infection and Immunity, 81(9), 3182–3197. https://doi.org/10.1128/IAI.00291-13.