Primary Information |
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| BoMiProt ID | Bomi204 |
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| Protein Name | ATP-binding cassette sub-family G member 2 |
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| Organism | Bos taurus |
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| Uniprot ID | Q4GZT4 |
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| Milk Fraction | MFGM, Exosome |
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| Ref Sequence ID | XP_005207851.1 |
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| Aminoacid Length | 655 |
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| Molecular Weight | 72725 |
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| FASTA Sequence |
Download |
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| Gene Name | ABCG2 |
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| Gene ID | 536203 |
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| Protein Existence Status | Reviewed: Protein inferred from homology |
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Secondary Information |
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| Protein Function | role in multidrug resistance (MDR) that efflux pumps as
P-glycoprotein |
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| Biochemical Properties | half-transporter”, hypothetically comprising a transmembrane domain (TMD)
with 6 α-helices that spawns the membrane bilayer and a nucleotide-binding domain (NBD) where ATP binds
and hydrolyzes; includes a second canonical ABC signature (positions 352–356, LSGGE) also coupled with
ATP binding and/or hydrolysis but not related with substrate specificity; |
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| Significance in milk | expressed in the bovine mammary gland at the onset of lactation; responsible for the major quantitave trait loci affecting milk yield and composition |
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| PTMs | intermolecular disulfide bond at position 603 |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | 6TMHs; (394-416), (428-450), (478-499), (506-528), (533-555), (629-651) |
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| Significance of PTMs | ABCG2 homodimerization was due to
the formation of an intermolecular disulfide bond at position 603 |
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| Bibliography | 1. Ferreira, R. J., Bonito, C. A., Cordeiro, M. N. D. S., Ferreira, M. J. U., & Dos Santos, D. J. V. A. (2017). Structure-function relationships in ABCG2: Insights from molecular dynamics simulations and molecular docking studies. Scientific Reports, 7(1). https://doi.org/10.1038/s41598-017-15452-z.
2. Cohen-Zinder, M., Seroussi, E., Larkin, D. M., Loor, J. J., Everts-van der Wind, A., Lee, J.-H., … Ron, M. (2005). Identification of a missense mutation in the bovine ABCG2 gene with a major effect on the QTL on chromosome 6 affecting milk yield and composition in Holstein cattle. Genome Research, 15(7), 936–944. https://doi.org/10.1101/gr.3806705. |
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