Search by BoMiProt ID - Bomi187

Primary Information

BoMiProt ID Bomi187
Protein Name Adenylyl cyclase-associated protein
Organism Bos taurus
Uniprot IDA6QLB7
Milk FractionWhey, Exosome
Ref Sequence ID XP_005204713.1
Aminoacid Length 471
Molecular Weight 51202
FASTA Sequence Download
Gene Name CAP1
Gene ID 504519
Protein Existence Status Unreviewed: Experimental evidence at transcript level

Secondary Information

Presence in other biological fluids/tissue/cells CAP1 is expressed in virtually all tissues and cells, whereas CAP2 is more specific and occurs mainly in skeletal and cardiac muscles, brain, and skin
Protein Function major function is to remodel the actin cytoskeleton; CAP proteins are involved in many cellular processes, directly or indirectly, through the regulation of actin dynamics and the cytoskeleton remodeling processes
Biochemical Properties In yeast, the N terminal domain of CAP participates in the Ras signaling pathway through binding to adenylate cyclase, an enzyme of the lyase class that catalyzes ATP formation in the presence of Mg2+ with production of pyrophosphoric acid and cAMP;
Significance in milk negatively regulate milk synthesis and proliferation of mammary epithelial cells via the PI3K‐mTOR/SREBP‐1c/Cyclin D1 signalling pathway
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Bibliography 1. Xie, S., Shen, C., Tan, M., Li, M., Song, X., & Wang, C. (2017). Systematic analysis of gene expression alterations and clinical outcomes of adenylate cyclase-associated protein in cancer. Oncotarget, 8(16), 27216–27239.
2. Hubberstey, A., Yu, G., Loewith, R., Lakusta, C., & Young, D. (1996). Mammalian CAP interacts with CAP, CAP2, and actin. Journal of Cellular Biochemistry, 61(3), 459–466.<459::AID-JCB13>3.0.CO;2-E.
3. Zhang, H., Ghai, P., Wu, H., Wang, C., Field, J., & Zhou, G. L. (2013). Mammalian adenylyl cyclase-associated protein 1 (CAP1) regulates cofilin function, the actin cytoskeleton, and cell adhesion. Journal of Biological Chemistry, 288(29), 20966–20977.
4. Jansen, S., Collins, A., Golden, L., Sokolova, O., & Goode, B. L. (2014). Structure and mechanism of mouse cyclase-associated protein (CAP1) in regulating actin dynamics. Journal of Biological Chemistry, 289(44), 30732–30742.
5. Yuan, X., Zhen, Z., Zhang, M., Yu, Y., Gao, X., & Ao, J.-X. (2019). Cyclase-associated protein 1 is a key negative regulator of milk synthesis and proliferation of bovine mammary epithelial cells. Cell Biochemistry and Function, 37(3), 185–192.