Primary Information |
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| BoMiProt ID | Bomi184 |
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| Protein Name | RRAS2 protein |
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| Organism | Bos taurus |
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| Uniprot ID | A5PKL2 |
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| Milk Fraction | MFGM, Exosome |
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| Ref Sequence ID | NP_001092480.1 |
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| Aminoacid Length | 204 |
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| Molecular Weight | 23400 |
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| FASTA Sequence |
Download |
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| Gene Name | RRAS2 |
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| Gene ID | 519269 |
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| Protein Existence Status | Unreviewed: Experimental evidence at transcript level |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | Tissues with the highest expression of the RRas2 mRNA included the lung and testis ;Tissues with moderate expression levels included different parts of the gut, the bladder, the white adipose tissue, the ovary, and, as expected , hematopoietic tissues such as the thymus and spleen;. Other tissues, such as the heart, trachea, a number of glands (adrenal, salivary, mammary, bulbourethral), kidney, eyes, skin, and the brain, showed lower levels of expression; Tissues with very low expression levels included the tongue, liver, skeletal muscle, and brown adipose |
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| Protein Function | Member of the Ras GTPase superfamily; role in signal
transduction, membrane trafficking, nuclear export/import, and cytoskeletal dynamics; critical for both embryonic and postnatal viability |
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| Significance in milk | important for proper mammary gland development |
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| PTMs | exhibited increased lysine fatty acylation in mouse embryonic fibroblast and Human Embryonic Kidney |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Significance of PTMs | Lysine fatty acylation promotes
the plasma membrane localization of R-Ras2 and its interaction with phosphatidylinositol 3-kinase
PI3K, leading to activated Akt and increased cell proliferation |
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| Bibliography | 1. Larive, R. M., Abad, A., Cardaba, C. M., Hernández, T., Cañamero, M., de Álava, E., … Bustelo, X. R. (2012). The Ras-like protein R-Ras2/TC21 is important for proper mammary gland development. Molecular Biology of the Cell, 23(12), 2373–2387. https://doi.org/10.1091/mbc.E12-01-0060.
2. Zhang, X., Spiegelman, N. A., Nelson, O. D., Jing, H., & Lin, H. (2017). SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation. ELife, 6. https://doi.org/10.7554/eLife.25158 |
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