Search by BoMiProt ID - Bomi184

Primary Information

BoMiProt ID Bomi184
Protein Name RRAS2 protein
Organism Bos taurus
Uniprot IDA5PKL2
Milk FractionMFGM, Exosome
Ref Sequence ID NP_001092480.1
Aminoacid Length 204
Molecular Weight 23400
FASTA Sequence Download
Gene Name RRAS2
Gene ID 519269
Protein Existence Status Unreviewed: Experimental evidence at transcript level

Secondary Information

Presence in other biological fluids/tissue/cells Tissues with the highest expression of the RRas2 mRNA included the lung and testis ;Tissues with moderate expression levels included different parts of the gut, the bladder, the white adipose tissue, the ovary, and, as expected , hematopoietic tissues such as the thymus and spleen;. Other tissues, such as the heart, trachea, a number of glands (adrenal, salivary, mammary, bulbourethral), kidney, eyes, skin, and the brain, showed lower levels of expression; Tissues with very low expression levels included the tongue, liver, skeletal muscle, and brown adipose
Protein Function Member of the Ras GTPase superfamily; role in signal transduction, membrane trafficking, nuclear export/import, and cytoskeletal dynamics; critical for both embryonic and postnatal viability
Significance in milk important for proper mammary gland development
PTMs exhibited increased lysine fatty acylation in mouse embryonic fibroblast and Human Embryonic Kidney
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Significance of PTMs Lysine fatty acylation promotes the plasma membrane localization of R-Ras2 and its interaction with phosphatidylinositol 3-kinase PI3K, leading to activated Akt and increased cell proliferation
Bibliography 1. Larive, R. M., Abad, A., Cardaba, C. M., Hernández, T., Cañamero, M., de Álava, E., … Bustelo, X. R. (2012). The Ras-like protein R-Ras2/TC21 is important for proper mammary gland development. Molecular Biology of the Cell, 23(12), 2373–2387.
2. Zhang, X., Spiegelman, N. A., Nelson, O. D., Jing, H., & Lin, H. (2017). SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation. ELife, 6.