Primary Information |
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| BoMiProt ID | Bomi172 |
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| Protein Name | Solute carrier organic anion transporter family, member 1A2 |
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| Organism | Bos taurus |
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| Uniprot ID | A2VDW7 |
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| Milk Fraction | Exosome |
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| Ref Sequence ID | XP_010803700.1 |
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| Aminoacid Length | 666 |
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| Molecular Weight | 73795 |
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| FASTA Sequence |
Download |
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| Gene Name | SLCO1A2 |
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| Gene ID | 282472 |
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| Protein Existence Status | Unreviewed: Experimental evidence at transcript level |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | brain, liver, and kidney; detected in the brain
capillary endothelium in humans; |
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| Protein Function | drug uptake transporter; mediate the cellular uptake of a large number of structurally
divergent compounds; play a critical role in the central nervous system penetration
of many drugs and hormones across the blood-brain barrier |
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| Biochemical Properties | broad substrate specificity- Substrates of OATP1A2
include endogenous compounds such as bile acids, steroid hormones,
and their conjugates, thyroid hormones, as well as
drugs including fexofenadine, ouabain, peptides (e.g. deltorphin
II, [D-penicillamine2,5]enkephalin, DPDPE), and the
toxin, microcystin |
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| Significance in milk | play pivotal roles in the delivery of e.g. vitamins, fatty acids, sterols, porphyrins, thyroid hormones, carnitine, and amino acids to the breast-fed offspring; mediate active transport also of drugs and toxic chemicals into milk |
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| PTMs | when expressed in HeLa cells, five putative
N-glycosylation sites were identified, including Asn residues
at the amino acid positions of 62, 124, 412, and 483 as well
as the 135 position |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Bibliography | 1. Yagdiran, Y., Oskarsson, A., Knight, C. H., & Tallkvist, J. (2016). ABC- and SLC-Transporters in Murine and Bovine Mammary Epithelium--Effects of Prochloraz. PloS One, 11(3), e0151904. https://doi.org/10.1371/journal.pone.0151904.
2. Lee, W., Glaeser, H., Smith, L. H., Roberts, R. L., Moeckel, G. W., Gervasini, G., … Kim, R. B. (2005). Polymorphisms in Human Organic Anion-transporting Polypeptide 1A2 (OATP1A2). Journal of Biological Chemistry, 280(10), 9610-9617 DO-10.1074/jbc.M411092200. https://doi.org/10.1074/jbc.M411092200. |
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