Primary Information
BoMiProt ID	Bomi170
Protein Name	Coronin, actin binding protein, 1C
Organism	Bos taurus
Uniprot ID	A2VDN8
Milk Fraction	MFGM, Exosome
Ref Sequence ID	NP_001075059.1
Aminoacid Length	474
Molecular Weight	53126
FASTA Sequence	Download
Gene Name	CORO1C
Gene ID	515798
Protein Existence Status	Unreviewed: Experimental evidence at transcript level
Secondary Information
Protein Function	actin-binding protein that has been implicated in chemotaxis in Dictyostelium; participate in actin remodeling; serve as a bridge between the actin cytoskeleton and the plasma membrane due to its membrane association; required for phagocytosis; Coronin 1A localizes to the F-actin rich membrane protrusions of activated T-lymphocytes; Coronin 1A enhances (rather than inhibits) cofilin-mediated actin disassembly
Biochemical Properties	undergoes reorganization during the polarization of the neutrophil, accumulating at the leading edge of the migrating cells
Significance in milk	cell differentiation;cell growth/tissue development; defence/immunity; lipid droplet transport/secretion; MFG protein which was significantly increased in abundance after S. uberis infection
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation
Bibliography	1. Thal, D., Xavier, C.-P., Rosentreter, A., Linder, S., Friedrichs, B., Waha, A., … Clemen, C. (2008). Expression of coronin-3 (coronin-1C) in diffuse gliomas is related to malignancy. The Journal of Pathology, 214(4), 415–424. https://doi.org/10.1002/path.2308. 2. Rosentreter, A., Hofmann, A., Xavier, C.-P., Stumpf, M., Noegel, A. A., & Clemen, C. S. (2007). Coronin 3 involvement in F-actin-dependent processes at the cell cortex. Experimental Cell Research, 313(5), 878–895. https://doi.org/10.1016/j.yexcr.2006.12.015. 3. Spoerl, Z., Stumpf, M., Noegel, A. A., & Hasse, A. (2002). Oligomerization, F-actin interaction, and membrane association of the ubiquitous mammalian coronin 3 are mediated by its carboxyl terminus. The Journal of Biological Chemistry, 277(50), 48858–48867. https://doi.org/10.1074/jbc.M205136200.