Search by BoMiProt ID - Bomi167

Primary Information

BoMiProt ID Bomi167
Protein Name Perilipin-2
Organism Bos taurus
Uniprot IDQ9TUM6
Milk FractionWhey
Ref Sequence ID NP_776405.1
Aminoacid Length 447
Molecular Weight 49102
FASTA Sequence Download
Gene Name PLIN2
Gene ID 280981
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondary Information

Presence in other biological fluids/tissue/cells adipose and steroidogenic tissue
Protein Function Transport proteins involved in lipid synthesis; mediate milk lipid formation and secretion; close correlation between full-length perilipin 2 expression and cytoplasmic lipid droplet accumulation is found
Biochemical Properties located at the periphery of the intracellular lipid droplets; lipidbinding domain at the N-terminus; cysteine residue inside the proposed amphipathic α-helix
Significance in milk related to milk-component synthesis- can be associated with the protection of the mammary gland; involved in mik lipid formation
PTMs phosphorylated
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 411-450
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs phosphorylation of perilipin is required for the translocation of hormone-sensitive lipase from the cytosol to the lipid droplet surface
Bibliography 1. Zhang, L., Boeren, S., Hageman, J. A., van Hooijdonk, T., Vervoort, J., & Hettinga, K. (2015). Perspective on calf and mammary gland development through changes in the bovine milk proteome over a complete lactation. Journal of Dairy Science, 98(8), 5362–5373.
2. Russell, T. D., Palmer, C. A., Orlicky, D. J., Bales, E. S., Chang, B. H.-J., Chan, L., & McManaman, J. L. (2008). Mammary glands of adipophilin-null mice produce an amino-terminally truncated form of adipophilin that mediates milk lipid droplet formation and secretion. Journal of Lipid Research, 49(1), 206–216.
3. Nielsen, R. L., Andersen, M. H., Mabhout, P., Berglund, L., Petersen, T. E., & Rasmussen, J. T. (1999). Isolation of adipophilin and butyrophilin from bovine milk and characterization of a cDNA encoding adipophilin. Journal of Dairy Science, 82(12), 2543–2549.
4. Xu, G., Sztalryd, C., Lu, X., Tansey, J. T., Gan, J., Dorward, H., … Londos, C. (2005). Post-translational regulation of adipose differentiation-related protein by the ubiquitin/proteasome pathway. The Journal of Biological Chemistry, 280(52), 42841–42847.
5. Najt, C. P., Lwande, J. S., McIntosh, A. L., Senthivinayagam, S., Gupta, S., Kuhn, L. A., & Atshaves, B. P. (2014). Structural and functional assessment of perilipin 2 lipid binding domain(s). Biochemistry, 53(45), 7051–7066.