Primary Information
BoMiProt ID	Bomi167
Protein Name	Perilipin-2
Organism	Bos taurus
Uniprot ID	Q9TUM6
Milk Fraction	Whey
Ref Sequence ID	NP_776405.1
Aminoacid Length	447
Molecular Weight	49102
FASTA Sequence	Download
Gene Name	PLIN2
Gene ID	280981
Protein Existence Status	Reviewed: Experimental evidence at transcript level
Secondary Information
Presence in other biological fluids/tissue/cells	adipose and steroidogenic tissue
Protein Function	Transport proteins involved in lipid synthesis; mediate milk lipid formation and secretion; close correlation between full-length perilipin 2 expression and cytoplasmic lipid droplet accumulation is found
Biochemical Properties	located at the periphery of the intracellular lipid droplets; lipidbinding domain at the N-terminus; cysteine residue inside the proposed amphipathic α-helix
Significance in milk	related to milk-component synthesis- can be associated with the protection of the mammary gland; involved in mik lipid formation
PTMs	phosphorylated
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation
Predicted Disorder Regions	411-450
DisProt Annotation
TM Helix Prediction	No TM helices
Significance of PTMs	phosphorylation of perilipin is required for the translocation of hormone-sensitive lipase from the cytosol to the lipid droplet surface
Bibliography	1. Zhang, L., Boeren, S., Hageman, J. A., van Hooijdonk, T., Vervoort, J., & Hettinga, K. (2015). Perspective on calf and mammary gland development through changes in the bovine milk proteome over a complete lactation. Journal of Dairy Science, 98(8), 5362–5373. https://doi.org/10.3168/jds.2015-9342. 2. Russell, T. D., Palmer, C. A., Orlicky, D. J., Bales, E. S., Chang, B. H.-J., Chan, L., & McManaman, J. L. (2008). Mammary glands of adipophilin-null mice produce an amino-terminally truncated form of adipophilin that mediates milk lipid droplet formation and secretion. Journal of Lipid Research, 49(1), 206–216. https://doi.org/10.1194/jlr.M700396-JLR200. 3. Nielsen, R. L., Andersen, M. H., Mabhout, P., Berglund, L., Petersen, T. E., & Rasmussen, J. T. (1999). Isolation of adipophilin and butyrophilin from bovine milk and characterization of a cDNA encoding adipophilin. Journal of Dairy Science, 82(12), 2543–2549. https://doi.org/10.3168/jds.S0022-0302(99)75508-6. 4. Xu, G., Sztalryd, C., Lu, X., Tansey, J. T., Gan, J., Dorward, H., … Londos, C. (2005). Post-translational regulation of adipose differentiation-related protein by the ubiquitin/proteasome pathway. The Journal of Biological Chemistry, 280(52), 42841–42847. https://doi.org/10.1074/jbc.M506569200. 5. Najt, C. P., Lwande, J. S., McIntosh, A. L., Senthivinayagam, S., Gupta, S., Kuhn, L. A., & Atshaves, B. P. (2014). Structural and functional assessment of perilipin 2 lipid binding domain(s). Biochemistry, 53(45), 7051–7066. https://doi.org/10.1021/bi500918m.