Search by BoMiProt ID - Bomi165

Primary Information

BoMiProt ID Bomi165
Protein Name Serpin A3-1
Organism Bos taurus
Uniprot IDQ9TTE1
Milk FractionWhey
Ref Sequence ID NP_777193.2
Aminoacid Length 411
Molecular Weight 46237
FASTA Sequence Download
Gene Name SERPINA3-1
Gene ID 286804
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondary Information

Presence in other biological fluids/tissue/cells hepatocytes, bronchial epithelial cells neuronal cells
Protein Function bovine plasma trypsin inhibitor; potent serine protease inhibitor with action against trypsin as well as elastase; serpin antiprotease α1-antichymotrypsin ; acute phase plasma protease inhibitor; regulation of proteases released by leukocytes during an inflammatory response; role in blood clotting cascade, apoptosis and chromatin condensation
Biochemical Properties inhibits chymotrypsin through direct binding; reactive centre loop (RCL) is partially inserted into the A β-sheet, a structural motif associated with ligand dependent activation in other serpins; RCL is stabilised by salt bridges; efficient inhibitor of human leukocyte elastase and cathepsin G
Significance in milk inhibit chymotrypsin, has a higher specificity for chymotrypsin than α1-antichymotrypsin
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1. Hwang, S. R., Steineckert, B., Kohn, A., Palkovits, M., & Hook, V. Y. (1999). Molecular studies define the primary structure of alpha1-antichymotrypsin (ACT) protease inhibitor in Alzheimer’s disease brains. Comparison of act in hippocampus and liver. The Journal of Biological Chemistry, 274(3), 1821–1827.
2. Cichy, J., Potempa, J., Chawla, R. K., & Travis, J. (1995). Regulation of alpha 1-antichymotrypsin synthesis in cells of epithelial origin. FEBS Letters, 359(2–3), 262–266.
3. Chandra, T., Stackhouse, R., Kidd, V. J., Robson, K. J. H., & Woo, S. L. C. (1983). Sequence Homology between Human α1-Antichymotrypsin, α1-Antitrypsin, and Antithrombin III. Biochemistry, 22(22), 5055–5061.