Primary Information |
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| BoMiProt ID | Bomi158 |
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| Protein Name | Lysozyme C, milk isozyme |
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| Organism | Bos taurus |
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| Uniprot ID | Q6B411 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001071297.1 |
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| Aminoacid Length | 148 |
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| Molecular Weight | 16783 |
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| FASTA Sequence |
Download |
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| Gene Name | LYZ1 |
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| Gene ID | 281287 |
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| Protein Existence Status | Reviewed: Experimental evidence at transcript level |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | tears, saliva, milk, mucus |
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| Protein Function | antimicrobial
activity; catalyses the hydrolysis of
glycosidic bonds of mucopolysaccharides in bacterial
cell walls; immune-regulatory activities,
inactivation of certain viruses; antiinflammatory; antitumour |
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| Biochemical Properties | Optimum pH
of 7.9 in 0.067 M phosphate buffer; require salts for activity; sodium citrate was the most potent
activator of the enzyme activity; sedimentation coefficient 2S; isoelectric point to be around pH 9.5; more stable in a.IS M KC1-o.o2 :M
sodium acetate buffer (pH 5.4) than in aqueous solution; labile at alkaline pH; Any treatment which "increases the acid character
of the molecule decreases the enzyme's potency, and the treatments which increase
its basic character increase its activity; |
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| Significance in milk | role of fighting infections in breastfeeding infants; natural antimicrobial agent; |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | 1. Ozturkoglu-Budak, S. (2018). Effect of different treatments on the stability of lysozyme, lactoferrin and β-lactoglobulin in donkey’s milk. International Journal of Dairy Technology, 71(1), 36–45. https://doi.org/10.1111/1471-0307.12380.
2. Chandan, R. C., Parry, R. M., & Shahani, K. M. (1965). Purification and some properties of bovine milk lysozyme. Biochimica et Biophysica Acta (BBA) - Enzymology and Biological Oxidation, 110(2), 389–398. https://doi.org/10.1016/S0926-6593(65)80046-7. |
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