Search by BoMiProt ID - Bomi151

Primary Information

BoMiProt ID Bomi151
Protein Name Syndecan binding protein (Syntenin)
Organism Bos taurus
Uniprot IDQ3SZA6
Milk FractionWhey
Ref Sequence ID NP_001068951.1
Aminoacid Length 298
Molecular Weight 32389
FASTA Sequence Download
Gene Name SDCBP
Gene ID 510979
Protein Existence Status Unreviewed: Experimental evidence at transcript level

Secondary Information

Protein Function might have flexible cell-type-specific roles, forming unique scaffolds that are dependent on the available intracellular environment; at least ten putative binding PDZ2 tandem, but neither the isolated domains nor partners reported for syntenin , including IL-5 receptor α-subunit, neuroglian, pro-TGFα
Biochemical Properties contain a tandem of PDZ domains exhibiting degenerate specificities; As a peptide binds to PDZ domains, it mimics an additional antiparallel strand in the sheet containing ß2; isolated PDZs have different stabilities; PDZ1 of one molecule interacts with PDZ2 of the adjacent one repoting self-association of syntenin;
Significance in milk IgA-inducing protein in colostrum
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Bibliography 1. Kang, B. S., Cooper, D. R., Jelen, F., Devedjiev, Y., Derewenda, U., Dauter, Z., Otlewski, J., and Derewenda, Z. S. (2003) PDZ tandem of human syntenin: crystal structure and functional properties. Structure 11, 459–468.
2. Grootjans, J. J., Zimmermann, P., Reekmans, G., Smets, A., Degeest, G., Dürr, J., and David, G. (1997) Syntenin, a PDZ protein that binds syndecan cytoplasmic domains. Proc. Natl. Acad. Sci. U. S. A. 94, 13683–13688.
3. Koroll, M., Rathjen, F. G., and Volkmer, H. (2001) The Neural Cell Recognition Molecule Neurofascin Interacts with Syntenin-1 but Not with Syntenin-2, Both of Which Reveal Self-associating Activity. J. Biol. Chem. 276, 10646–10654.