|Ref Sequence ID||NP_001029434.1|
|Protein Existence Status||Reviewed: Experimental evidence at transcript level|
|Presence in other biological fluids/tissue/cells||fetal liver, yolk sac of mammals; bovine fetal fluids; ascitic fluid, cerebrospinal fluid (CSF) and bile, from human fetuses;|
|Protein Function||contribute to the efficiency of stimulation of proliferation in cell culture systems; growth-promoting activity;|
|Biochemical Properties||charge microheterogeneity in the bAFP indirectly suggests that the multiple bands may be due to carbohydrate; charge profile of bovine AFPsignificantly more alkaline than that observed in the human; greater degree of charge microheterogeneity than the human;|
|Significance in milk||Innate immunity agents in milk|
|PTMs||glycoprotein; bAFP in FBS is approximately evenly divided between Con A reactive and non-reactive variants; bAFP in amniotic fluid from an early gestation animal exhibited 72% reactive and 28% non-reactive variants|
| Site(s) of PTM(s) |
|Predicted Disorder Regions||NA|
|TM Helix Prediction||No TM helices|
|Significance of PTMs||significant changes in lectin-binding properties of glycoproteins are associated with normal and tumor cell growth as well as fetal development; non-reactive variants of bAFP in FBS increases in parallel with fetal development;|
|Bibliography||1. Smith, J. A., Francis, T. I., Edington, G. M., & Williams, A. O. (1971). Human alpha fetoprotein in body fluids. British Journal of Cancer, 25(2), 337–342. https://doi.org/10.1038/bjc.1971.43. |
2. Janzen, R. G., Mably, E. R., Tamaoki, T., Church, R. B., & Lorscheider, F. L. (1982). Synthesis of alpha-fetoprotein by the pre-implantation and post-implantation bovine embryo. Journal of Reproduction and Fertility, 65(1), 105–110. https://doi.org/10.1530/jrf.0.0650105.
3. He, Y., & Keel, B. A. (1994). Biochemical characterization of bovine alpha-fetoprotein and comparison with human alpha-fetoprotein. Comparative Biochemistry and Physiology. Biochemistry and Molecular Biology, 108(3), 327–336. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/7521727.