Search by BoMiProt ID - Bomi150

Primary Information

BoMiProt ID Bomi150
Protein Name Alpha-fetoprotein
Organism Bos taurus
Uniprot IDQ3SZ57
Milk FractionWhey
Ref Sequence ID NP_001029434.1
Aminoacid Length 610
Molecular Weight 68588
FASTA Sequence Download
Gene Name AFP
Gene ID 506011
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondary Information

Presence in other biological fluids/tissue/cells fetal liver, yolk sac of mammals; bovine fetal fluids; ascitic fluid, cerebrospinal fluid (CSF) and bile, from human fetuses;
Protein Function contribute to the efficiency of stimulation of proliferation in cell culture systems; growth-promoting activity;
Biochemical Properties charge microheterogeneity in the bAFP indirectly suggests that the multiple bands may be due to carbohydrate; charge profile of bovine AFPsignificantly more alkaline than that observed in the human; greater degree of charge microheterogeneity than the human;
Significance in milk Innate immunity agents in milk
PTMs glycoprotein; bAFP in FBS is approximately evenly divided between Con A reactive and non-reactive variants; bAFP in amniotic fluid from an early gestation animal exhibited 72% reactive and 28% non-reactive variants
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs significant changes in lectin-binding properties of glycoproteins are associated with normal and tumor cell growth as well as fetal development; non-reactive variants of bAFP in FBS increases in parallel with fetal development;
Bibliography 1. Smith, J. A., Francis, T. I., Edington, G. M., & Williams, A. O. (1971). Human alpha fetoprotein in body fluids. British Journal of Cancer, 25(2), 337–342.
2. Janzen, R. G., Mably, E. R., Tamaoki, T., Church, R. B., & Lorscheider, F. L. (1982). Synthesis of alpha-fetoprotein by the pre-implantation and post-implantation bovine embryo. Journal of Reproduction and Fertility, 65(1), 105–110.
3. He, Y., & Keel, B. A. (1994). Biochemical characterization of bovine alpha-fetoprotein and comparison with human alpha-fetoprotein. Comparative Biochemistry and Physiology. Biochemistry and Molecular Biology, 108(3), 327–336. Retrieved from