|Ref Sequence ID||NP_001029799.1|
|Protein Existence Status||Reviewed: Experimental evidence at transcript level|
|Protein Function||Gelsolin superfamily proteins have roles in a diversity of cellular processes; regulation of actin dynamics; antiapoptotic role; inhibit Aß-induced neurotoxicity; increased expression of gelsolin in oxidative stress helps cells to escape death. Gelsolin is a calcium-regulated actin binding protein that severs and caps actin filaments. Gelsolin's severing activity is important for regulating actin filament assembly dynamics that are required for cell motility as well as survival.|
|Biochemical Properties||on calcium or pH signaling, gelsolin becomes activated and can sever actin filaments;|
|Significance in milk||downregulated in clinical mastitis|
|PTMs||N6-acetylation at Lysine, Disulfide bond formation, Phosphorylation at Tyr/Thr|
| Site(s) of PTM(s) |
|Predicted Disorder Regions||(197-216)|
|TM Helix Prediction||No TM helices|
|Bibliography||1. Chauhan, V., Ji, L., & Chauhan, A. (2008). Anti-amyloidogenic, anti-oxidant and anti-apoptotic role of gelsolin in Alzheimer’s disease. Biogerontology, 9(6), 381–389. https://doi.org/10.1007/s10522-008-9169-z. |
2. Kiselar, J. G., Janmey, P. A., Almo, S. C., & Chance, M. R. (2003). Visualizing the Ca2+-dependent activation of gelsolin by using synchrotron footprinting. Proceedings of the National Academy of Sciences of the United States of America, 100(7), 3942–3947. https://doi.org/10.1073/pnas.0736004100.
3. Lueck, A., Yin, H. L., Kwiatkowski, D. J., & Allen, P. G. (2000). Calcium regulation of gelsolin and adseverin: a natural test of the helix latch hypothesis. Biochemistry, 39(18), 5274–5279. https://doi.org/10.1021/bi992871v. 4.Heidings JB, Demosthene B, Merlino TR, Castaneda N, Kang EH. Gelsolin-mediated actin filament severing in crowded environments. Biochem Biophys Res Commun. 2020 Nov 19;532(4):548-554. doi: 10.1016/j.bbrc.2020.08.041. Epub 2020 Sep 6. PMID: 32900483.