Search by BoMiProt ID - Bomi144

Primary Information

BoMiProt ID Bomi144
Protein Name Tetranectin
Organism Bos taurus
Uniprot IDQ2KIS7
Milk FractionWhey
Ref Sequence ID NP_001039677.1
Aminoacid Length 202
Molecular Weight 22144
FASTA Sequence Download
Gene Name CLEC3B
Gene ID 515783
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondary Information

Presence in other biological fluids/tissue/cells including monocytes, neutrophils, fibroblasts, osteoblasts, extracellular matrix of certain human carcinomas (breast, colonic, and ovarian tumors
Protein Function role in the invasive process, in mineralization during osteogenesis; target plasminogen to specific carbohydrate ligands on cell surfaces, in the extracellular matrix or to fibrin
Biochemical Properties homotrimeric protein; bind specifically to the kringle 4 domain of plasminogen; interacts in a calcium-dependent manner with sulfated polysaccharides, fibrin and apolipoprotein; contains a carbohydrate recognition domain
Significance in milk Expression increases during mammary involution process
PTMs contains a long-form carbohydrate recognition domain with three disulfide bridges
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1. Boggs, I., Hine, B., Smolenski, G., Hettinga, K., Zhang, L., & Wheeler, T. T. (2015). Changes in the repertoire of bovine milk proteins during mammary involution. EuPA Open Proteomics, 9, 65–75.
2. Nielsen, B. B., Kastrup, J. S., Rasmussen, H., Holtet, T. L., Graversen, J. H., Etzerodt, M., … Larsen, I. K. (1997). Crystal structure of tetranectin, a trimeric plasminogen-binding protein with an alpha-helical coiled coil. FEBS Letters, 412(2), 388–396.