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Primary Information | |
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| BoMiProt ID | Bomi143 |
| Protein Name | Carboxypeptidase B2 |
| Organism | Bos taurus |
| Uniprot ID | Q2KIG3 |
| Milk Fraction | Whey |
| Ref Sequence ID | NP_001039462.1 |
| Aminoacid Length | 423 |
| Molecular Weight | 48822 |
| FASTA Sequence | Download |
| Gene Name | CPB2 |
| Gene ID | 508222 |
| Protein Existence Status | Reviewed: Experimental evidence at protein level |
Secondary Information | |
| Protein Function | enzyme that selectively catalyzes the release of the carboxyl-terminal basic amino acids, arginine and lysine, from proteins and peptides; possess esterase activity toward hippuryl-n-argininic acid |
| Biochemical Properties | The inhibition of the enzyme by phosphate and that by citrate are pH-dependent and are most pronounced below pH 6.5; decreasing effectiveness as inhibitors at pH 8: NaI, KSCN, NaBr, MgS04, NaCI, KCl, and NaN03; |
| Significance in milk | belong to the protease system in milk |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | |
| SCOP | Class : Alpha and beta proteins (a/b) Fold : Phosphorylase/hydrolase-like Superfamily : Zn-dependent exopeptidases Family : Pancreatic carboxypeptidase-like Domain Name : 3D4U A:7-308 |
| CATH | Matched CATH superfamily 3.30.70.340 3.40.630.10 |
| Predicted Disorder Regions | (1-117) |
| DisProt Annotation | |
| TM Helix Prediction | No TM helices |
| PDB ID | 3D4U, 3DGV, 3OSL, |
| Bibliography | 1. FOLK, J. E., WOLFF, E. C., & SCHIRMER, E. W. (1962). The kinetics of carboxypeptidase B activity. II. Kinetic parameters of the cobalt and cadmium enzymes. The Journal of Biological Chemistry, 237, 3100–3104. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/13945772 |