Search by BoMiProt ID - Bomi142

Primary Information

BoMiProt ID Bomi142
Protein Name Leucine-rich alpha-2-glycoprotein
Organism Bos taurus
Uniprot IDQ2KIF2
Milk FractionWhey
Ref Sequence ID NP_001039642.1
Aminoacid Length 346
Molecular Weight 38348
FASTA Sequence Download
Gene Name LRG1
Gene ID 514663
Protein Existence Status Unreviewed: Experimental evidence at protein level

Secondary Information

Presence in other biological fluids/tissue/cells serum, hepatocytes
Protein Function a serum protein which has been implicated in angiogenesis and tumor promotion; expression increases in response to mediators of the acute-phase response and bacterial infections; roles in cell survival, migration, invasion, and apoptosis
Biochemical Properties single polypeptide chain; multiple binding partners; binds to cytochrome c and TGFβ1; amino acid sequence can be exactly divided into 13 segments of 24 residues each, eight of which exhibit a periodic pattern in the occurrence of leucine, proline, and asparagine
Significance in milk Found in whey; Has a role in inflammation
PTMs has two intrachain disulfide bonds; one galactosamine and four glucosamine oligosaccharides attached;
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Significance of PTMs disulfide bond and the carbohydrate suggest that LRG is a membrane-derived or membrane-associated protein containing a series of domains capable of bipolar surface orientation
Bibliography 1. Druhan, L. J., Lance, A., Li, S., Price, A. E., Emerson, J. T., Baxter, S. A., … Avalos, B. R. (2017). Leucine Rich α-2 Glycoprotein: A Novel Neutrophil Granule Protein and Modulator of Myelopoiesis. PloS One, 12(1), e0170261.
2. Takahashi, N., Takahashi, Y., & Putnam, F. W. (1985). Periodicity of leucine and tandem repetition of a 24-amino acid segment in the primary structure of leucine-rich alpha 2-glycoprotein of human serum. Proceedings of the National Academy of Sciences of the United States of America, 82(7), 1906–1910.
3. Sun, D.-C., Shi, Y., Wang, L.-X., Lv, Y., Han, Q.-L., Wang, Z.-K., & Dai, G.-H. (2017). Leucine-rich alpha-2-glycoprotein-1, relevant with microvessel density, is an independent survival prognostic factor for stage III colorectal cancer patients: a retrospective analysis. Oncotarget, 8(39), 66550–66558.