|Protein Name||Leucine-rich alpha-2-glycoprotein|
|Ref Sequence ID||NP_001039642.1|
|Protein Existence Status||Unreviewed: Experimental evidence at protein level|
|Presence in other biological fluids/tissue/cells||serum, hepatocytes|
|Protein Function||a serum protein which has been implicated in angiogenesis and tumor promotion; expression increases in response to mediators of the acute-phase response and bacterial infections; roles in cell survival, migration, invasion, and apoptosis|
|Biochemical Properties||single polypeptide chain; multiple binding partners; binds to cytochrome c and TGFβ1; amino acid sequence can be exactly divided into 13 segments of 24 residues each, eight of which exhibit a periodic pattern in the occurrence of leucine, proline, and asparagine|
|Significance in milk||Found in whey; Has a role in inflammation|
|PTMs||has two intrachain disulfide bonds; one galactosamine and four glucosamine oligosaccharides attached;|
| Site(s) of PTM(s) |
|Significance of PTMs||disulfide bond and the carbohydrate suggest that LRG is a membrane-derived or membrane-associated protein containing a series of domains capable of bipolar surface orientation|
|Bibliography||1. Druhan, L. J., Lance, A., Li, S., Price, A. E., Emerson, J. T., Baxter, S. A., … Avalos, B. R. (2017). Leucine Rich α-2 Glycoprotein: A Novel Neutrophil Granule Protein and Modulator of Myelopoiesis. PloS One, 12(1), e0170261. https://doi.org/10.1371/journal.pone.0170261. |
2. Takahashi, N., Takahashi, Y., & Putnam, F. W. (1985). Periodicity of leucine and tandem repetition of a 24-amino acid segment in the primary structure of leucine-rich alpha 2-glycoprotein of human serum. Proceedings of the National Academy of Sciences of the United States of America, 82(7), 1906–1910. https://doi.org/10.1073/pnas.82.7.1906.
3. Sun, D.-C., Shi, Y., Wang, L.-X., Lv, Y., Han, Q.-L., Wang, Z.-K., & Dai, G.-H. (2017). Leucine-rich alpha-2-glycoprotein-1, relevant with microvessel density, is an independent survival prognostic factor for stage III colorectal cancer patients: a retrospective analysis. Oncotarget, 8(39), 66550–66558. https://doi.org/10.18632/oncotarget.16289.