Search by BoMiProt ID - Bomi136

Primary Information

BoMiProt ID Bomi136
Protein Name Nucleobindin 2
Organism Bos taurus
Uniprot IDQ0IIH5
Milk FractionWhey
Ref Sequence ID NP_001068849.1
Aminoacid Length 415
Molecular Weight 49188
FASTA Sequence Download
Gene Name NUCB2
Gene ID 509003
Protein Existence Status Unreviewed: Experimental evidence at protein level

Secondary Information

Presence in other biological fluids/tissue/cells Serum
Protein Function Regulates appetite; production of body fat; role in glucose metabolism; acts as a substrate for caspase 3, 6 and 8
Biochemical Properties Calcium binding activity; α-helical content increases on binding with calcium; proteolytic digestion changes on calcium binding
Significance in milk Important for growth, bone formation, energy regulation and maturation of the gastrointestinal system in neonates
PTMs Phosphorylated as found in gastric mucosa; might be glycosylated
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Bibliography 1. Miura, K., Kurosawa, Y., and Kanai, Y. (1994) Calcium-Binding Activity of Nucleobindin Mediated by an EF Hand Moiety. Biochem. Biophys. Res. Commun. 199, 1388–1393.
2. Kroll, K. A., Otte, S., Hirschfeld, G., Barnikol-Watanabe, S., Götz, H., Sternbach, H., Kratzin, H. D., Barnikol, H. U., and Hilschmann, N. (1999) Heterologous overexpression of human NEFA and studies on the two EF-hand calcium-binding sites. Biochem. Biophys. Res. Commun. 260, 1–8.
3. Valencia, C. A., Cotten, S. W., Duan, J., and Liu, R. (2008) Modulation of nucleobindin-1 and nucleobindin-2 by caspases. FEBS Lett. 582, 286–290.
4. Kalnina, Z., Silina, K., Bruvere, R., Gabruseva, N., Stengrevics, A., Barnikol-Watanabe, S., Leja, M., and Line, A. Molecular characterisation and expression analysis of SEREX-defined antigen NUCB2 in gastric epithelium, gastritis and gastric cancer. Eur. J. Histochem. 53, 7–18.
5. Aydin, S. (2010) The presence of the peptides apelin, ghrelin and nesfatin-1 in the human breast milk, and the lowering of their levels in patients with gestational diabetes mellitus. Peptides 31, 2236–2240