Primary Information |
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| BoMiProt ID | Bomi134 |
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| Protein Name | Polymeric immunoglobulin receptor |
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| Organism | Bos taurus |
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| Uniprot ID | P81265 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_776568.1 |
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| Aminoacid Length | 757 |
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| Molecular Weight | 82435 |
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| FASTA Sequence |
Download |
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| Gene Name | PIGR |
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| Gene ID | 281401 |
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| Protein Existence Status | Reviewed: Experimental evidence at transcript level |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | saliva, intestinal secretions, bile, respiratory
secretions, and tears |
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| Protein Function | Transcytosed in intestinal epithelial cells, proteolytically cleaved at apical plasma membrane into secretory component and transmembrane segment; binds to IgA and IgM and protect them from proteolytic degradation; promotes internal neutralization of some viruses; binds to bacterial components of Streptococcus pneumonia and prevent their invasion on respiratory epithelial cells |
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| Biochemical Properties | Secretory component can stabilize interactions with dimeric IgA by forming a covalent bond between one of its domains, D5 and a cysteine residue on polymeric IgA |
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| Significance in milk | Important for the establishment of intestinal microbiota |
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| PTMs | Heavily N-glycosylated; contains glucose, N-acetylglucosamine, N-acetylgalactosamine.
and N-acetylneuraminic acid as detected in human colustrum |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | 607-627,679-730 |
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| DisProt Annotation | |
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| TM Helix Prediction | 1TMH; (631-653) |
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| Bibliography | 1. Lu, L., Lamm, M. E., Li, H., Corthesy, B., and Zhang, J.-R. (2003) The human polymeric immunoglobulin receptor binds to Streptococcus pneumoniae via domains 3 and 4. J. Biol. Chem. 278, 48178–48187.
2. Tomana, M., Niedermeier, W., and Spivey, C. (1978) Microdetermination of monosaccharides in glycoproteins by gas-liquid chromatography. Anal. Biochem. 89, 110–118. |
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