Search by BoMiProt ID - Bomi134

Primary Information

BoMiProt ID Bomi134
Protein Name Polymeric immunoglobulin receptor
Organism Bos taurus
Uniprot IDP81265
Milk FractionWhey
Ref Sequence ID NP_776568.1
Aminoacid Length 757
Molecular Weight 82435
FASTA Sequence Download
Gene Name PIGR
Gene ID 281401
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondary Information

Presence in other biological fluids/tissue/cells saliva, intestinal secretions, bile, respiratory secretions, and tears
Protein Function Transcytosed in intestinal epithelial cells, proteolytically cleaved at apical plasma membrane into secretory component and transmembrane segment; binds to IgA and IgM and protect them from proteolytic degradation; promotes internal neutralization of some viruses; binds to bacterial components of Streptococcus pneumonia and prevent their invasion on respiratory epithelial cells
Biochemical Properties Secretory component can stabilize interactions with dimeric IgA by forming a covalent bond between one of its domains, D5 and a cysteine residue on polymeric IgA
Significance in milk Important for the establishment of intestinal microbiota
PTMs Heavily N-glycosylated; contains glucose, N-acetylglucosamine, N-acetylgalactosamine. and N-acetylneuraminic acid as detected in human colustrum
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 607-627,679-730
DisProt Annotation
TM Helix Prediction 1TMH; (631-653)
Bibliography 1. Lu, L., Lamm, M. E., Li, H., Corthesy, B., and Zhang, J.-R. (2003) The human polymeric immunoglobulin receptor binds to Streptococcus pneumoniae via domains 3 and 4. J. Biol. Chem. 278, 48178–48187.
2. Tomana, M., Niedermeier, W., and Spivey, C. (1978) Microdetermination of monosaccharides in glycoproteins by gas-liquid chromatography. Anal. Biochem. 89, 110–118.