Search by BoMiProt ID - Bomi130

Primary Information

BoMiProt ID Bomi130
Protein Name Protein S100-A12
Organism Bos taurus
Uniprot IDP79105
Milk FractionWhey
Ref Sequence ID NP_777076.1
Aminoacid Length 92
Molecular Weight 10685
FASTA Sequence Download
Gene Name S100A12
Gene ID 282467
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondary Information

Presence in other biological fluids/tissue/cells neutrophils, monocytes, smooth muscle cells;
Protein Function important mediators in many different cellular functions involving immunity, inflammation, cell proliferation, apoptosis and other activities; expression of S100A12 increased at some cases of human inflammatory diseases; modulate interactions between cytoskeletal elements and membranes; inhibits aggregation of aldolase and GAPDH and may have Ca2+-dependent chaperone/anti-chaperone-like functions; play a role in vascular remodeling
Biochemical Properties calcium binding proteins; hinge domain are chemotactic for monocytes and mast cells; presence of a pseudo‐EF‐hand calcium‐binding site
Significance in milk S100A12 was positively associated with the somatic cell count and the sodium and chloride concentrations of milk; a negative correlation was found between S100A12 and the potassium concentration and pH of milk; S100A12 level in milk may serve as a diagnostic tool for subclinical mastitis in cows without obvious clinical signs
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1. Zhong, K., Zhang, C.-Y., Zha, G.-M., Wang, X.-J., Jiao, X.-Q., Zhu, H.-S., & Wang, Y.-Y. (2018). S100 calcium-binding protein A12 as a diagnostic index for subclinical mastitis in cows. Reproduction in Domestic Animals = Zuchthygiene, 53(6), 1442–1447.
2. Hofmann Bowman, M., Wilk, J., Heydemann, A., Kim, G., Rehman, J., Lodato, J. A., … McNally, E. M. (2010). S100A12 mediates aortic wall remodeling and aortic aneurysm. Circulation Research, 106(1), 145–154.
3. Hatakeyama, T., Okada, M., Shimamoto, S., Kubota, Y., & Kobayashi, R. (2004). Identification of intracellular target proteins of the calcium-signaling protein S100A12. European Journal of Biochemistry, 271(18), 3765–3775.
4. Vogl, T., Pröpper, C., Hartmann, M., Strey, A., Strupat, K., van den Bos, C., … Roth, J. (1999). S100A12 is expressed exclusively by granulocytes and acts independently from MRP8 and MRP14. The Journal of Biological Chemistry, 274(36), 25291–25296.