Primary Information |
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| BoMiProt ID | Bomi13 |
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| Protein Name | Cathelicidin-1 |
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| Organism | Bos taurus |
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| Uniprot ID | P22226 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_777250.1 |
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| Aminoacid Length | 155 |
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| Molecular Weight | 17600 |
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| FASTA Sequence |
Download |
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| Gene Name | CATHL1 |
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| Gene ID | 282164 |
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| Protein Existence Status | Reviewed: Experimental evidence at protein level |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | neutrophils present in peripheral blood, bone marrow, spleen, or liver |
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| Protein Function | bactericidal activity against both Escherichia coli and Staphylococcus aureus; |
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| Biochemical Properties | cysteine-rich bactenecin maintained a
cyclic structure by a disulfide bond between the two
cysteine residues; cyclic dodecapeptide; structure similar to defensins |
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| Significance in milk | initial response of the mammary epithelium to microbial infection |
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| PTMs | Disulfide bond formation, Pyrrolidone carboxylic acid attachment |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | 1-5,51-76,88-93,129-130 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Antimicrobial peptides and upregulated in mastitis |
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| Additional Comments | Stored in neutrophil granules in inactive forms; enzymatically cleaved into active peptides by neutrophil granule contents; bactenecin’s expression is
concomitant with granulopoiesis during fetal life |
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| Bibliography | 1. Romeo, D., Skerlavaj, B., Bolognesi, M., and Gennaro, R. (1988) Structure and bactericidal activity of an antibiotic dodecapeptide purified from bovine neutrophils. J. Biol. Chem. 263, 9573–9575.
2. 1. Smith, W. L., Sunaga, O., and Cullor, J. S. (1999) An evaluation of the tissue expression of a bovine dodecapeptide bactenecin in the adult and fetal animal. Comp. Haematol. Int. 9, 132–138 |
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