Search by BoMiProt ID - Bomi13

Primary Information

BoMiProt ID Bomi13
Protein Name Cathelicidin-1
Organism Bos taurus
Uniprot IDP22226
Milk FractionWhey
Ref Sequence ID NP_777250.1
Aminoacid Length 155
Molecular Weight 17600
FASTA Sequence Download
Gene Name CATHL1
Gene ID 282164
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondary Information

Presence in other biological fluids/tissue/cells neutrophils present in peripheral blood, bone marrow, spleen, or liver
Protein Function bactericidal activity against both Escherichia coli and Staphylococcus aureus;
Biochemical Properties cysteine-rich bactenecin maintained a cyclic structure by a disulfide bond between the two cysteine residues; cyclic dodecapeptide; structure similar to defensins
Significance in milk initial response of the mammary epithelium to microbial infection
PTMs Disulfide bond formation, Pyrrolidone carboxylic acid attachment
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 1-5,51-76,88-93,129-130
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Antimicrobial peptides and upregulated in mastitis
Additional Comments Stored in neutrophil granules in inactive forms; enzymatically cleaved into active peptides by neutrophil granule contents; bactenecin’s expression is concomitant with granulopoiesis during fetal life
Bibliography 1. Romeo, D., Skerlavaj, B., Bolognesi, M., and Gennaro, R. (1988) Structure and bactericidal activity of an antibiotic dodecapeptide purified from bovine neutrophils. J. Biol. Chem. 263, 9573–9575.
2. 1. Smith, W. L., Sunaga, O., and Cullor, J. S. (1999) An evaluation of the tissue expression of a bovine dodecapeptide bactenecin in the adult and fetal animal. Comp. Haematol. Int. 9, 132–138