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Primary Information | |
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| BoMiProt ID | Bomi128 |
| Protein Name | Cathelicidin-7 |
| Organism | Bos taurus |
| Uniprot ID | P56425 |
| Milk Fraction | Whey |
| Ref Sequence ID | NP_777256.1 |
| Aminoacid Length | 165 |
| Molecular Weight | 18848 |
| FASTA Sequence | Download |
| Gene Name | CATHL7 |
| Gene ID | 317650 |
| Protein Existence Status | Reviewed: Experimental evidence at transcript level |
Secondary Information | |
| Protein Function | broad– spectrum activity against fungi and Gram-negative and Grampositive bacteria, including MRSA and P. aeruginosa; is inactive against eukaryotic cells |
| Biochemical Properties | amphipathic peptide; overall positive charge (+8); α-helical bovine myeloid antimicrobial peptides; no hydrophobic C terminal; |
| Significance in milk | initial response of the mammary epithelium to microbial infection |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | |
| Predicted Disorder Regions | 1-7,61-74,86-96,142-143, |
| DisProt Annotation | |
| TM Helix Prediction | No TM helices |
| Significance of PTMs | Antimicrobial peptides and upregulated in mastitis |
| PDB ID | _, |
| Bibliography | 1. Tomasinsig, L., Benincasa, M., Scocchi, M., Skerlavaj, B., Tossi, A., Zanetti, M., and Gennaro, R. (2010) Role of Cathelicidin Peptides in Bovine Host Defense and Healing. Probiotics Antimicrob. Proteins 2, 12–20. 2. Baumann, A., Kiener, M. S., Haigh, B., Perreten, V., and Summerfield, A. (2017) Differential Ability of Bovine Antimicrobial Cathelicidins to Mediate Nucleic Acid Sensing by Epithelial Cells. Front. Immunol. 8, 59. 3. 1. Gennaro, R., Scocchi, M., Merluzzi, L., and Zanetti, M. (1998) Biological characterization of a novel mammalian antimicrobial peptide. Biochim. Biophys. Acta 1425, 361–368. 4. 1. Scocchi, M., Wang, S., and Zanetti, M. (1997) Structural organization of the bovine cathelicidin gene family and identification of a novel member. FEBS Lett. 417, 311–315. |