Search by BoMiProt ID - Bomi128

Primary Information

BoMiProt ID Bomi128
Protein Name Cathelicidin-7
Organism Bos taurus
Uniprot IDP56425
Milk FractionWhey
Ref Sequence ID NP_777256.1
Aminoacid Length 165
Molecular Weight 18848
FASTA Sequence Download
Gene Name CATHL7
Gene ID 317650
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondary Information

Protein Function broad– spectrum activity against fungi and Gram-negative and Grampositive bacteria, including MRSA and P. aeruginosa; is inactive against eukaryotic cells
Biochemical Properties amphipathic peptide; overall positive charge (+8); α-helical bovine myeloid antimicrobial peptides; no hydrophobic C terminal;
Significance in milk initial response of the mammary epithelium to microbial infection
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 1-7,61-74,86-96,142-143,
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Antimicrobial peptides and upregulated in mastitis
Bibliography 1. Tomasinsig, L., Benincasa, M., Scocchi, M., Skerlavaj, B., Tossi, A., Zanetti, M., and Gennaro, R. (2010) Role of Cathelicidin Peptides in Bovine Host Defense and Healing. Probiotics Antimicrob. Proteins 2, 12–20.
2. Baumann, A., Kiener, M. S., Haigh, B., Perreten, V., and Summerfield, A. (2017) Differential Ability of Bovine Antimicrobial Cathelicidins to Mediate Nucleic Acid Sensing by Epithelial Cells. Front. Immunol. 8, 59.
3. 1. Gennaro, R., Scocchi, M., Merluzzi, L., and Zanetti, M. (1998) Biological characterization of a novel mammalian antimicrobial peptide. Biochim. Biophys. Acta 1425, 361–368.
4. 1. Scocchi, M., Wang, S., and Zanetti, M. (1997) Structural organization of the bovine cathelicidin gene family and identification of a novel member. FEBS Lett. 417, 311–315.