Search by BoMiProt ID - Bomi127

Primary Information

BoMiProt ID Bomi127
Protein Name Cathelicidin-5
Organism Bos taurus
Uniprot IDP54229
Milk FractionWhey
Ref Sequence ID NP_776935.1
Aminoacid Length 159
Molecular Weight 17616
FASTA Sequence Download
Gene Name CATHL5
Gene ID 282167
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondary Information

Protein Function the effect of BMAP-28 on S. aureus may be complex and include promoting bacterial pathogenesis; increased adherence of S. aureus to host fibronectin, collagen type I and collagen type IV; spirochetes are susceptible to BMAP-28; antiparasitic activity against two strains of L. major; caused greater inhibition of release of lipoteichoic acid (LTA)-induced TNF-α, IL-6 and nitric oxide from Gram-positive bacteria; can induce immunomodulatory effects on leukocytes depending on the pathogen and surrounding cytokine milieu
Biochemical Properties α-helical bovine myeloid antimicrobial peptides; hydrophobic C-terminal
Significance in milk initial response of the mammary epithelium to microbial infection
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
CATH Matched CATH superfamily
Predicted Disorder Regions 1-5,55-76,88-97
DisProt Annotation
TM Helix Prediction 1TMH; (13-31)
Significance of PTMs Antimicrobial peptides and upregulated in mastitis
Bibliography 1. Giacometti, A., Cirioni, O., Ghiselli, R., Bergnach, C., Orlando, F., D’Amato, G., Mocchegiani, F., Silvestri, C., Del Prete, M. S., Skerlavaj, B., Saba, V., Zanetti, M., and Scalise, G. (2004) The antimicrobial peptide BMAP-28 reduces lethality in mouse models of staphylococcal sepsis. Crit. Care Med. 32, 2485–2490.
2. 1. Lynn, M. A., Kindrachuk, J., Marr, A. K., Jenssen, H., Panté, N., Elliott, M. R., Napper, S., Hancock, R. E., and McMaster, W. R. (2011) Effect of BMAP-28 Antimicrobial Peptides on Leishmania major Promastigote and Amastigote Growth: Role of Leishmanolysin in Parasite Survival. PLoS Negl. Trop. Dis. 5, e1141.
3. 1. Takagi, S., Bai, L., Ozeki, T., Miyagi, H., Kuroda, K., Hayashi, S., Yoneyama, H., Ando, T., and Isogai, E. (2014) A bovine myeloid antimicrobial peptide (BMAP-28) kills methicillin-resistant Staphylococcus aureus but promotes adherence of the bacteria. Anim. Sci. J. 85, 342–346.