Search by BoMiProt ID - Bomi126

Primary Information

BoMiProt ID Bomi126
Protein Name Cathelicidin-6
Organism Bos taurus
Uniprot IDP54228
Milk FractionWhey
Ref Sequence ID NP_777257.1
Aminoacid Length 158
Molecular Weight 17852
FASTA Sequence Download
Gene Name CATHL6
Gene ID 317651
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondary Information

Protein Function Scrambled BMAP–27 has reduced antimicrobial action against S. aureus, S. uberis and E. coli compared with unmodified BMAP-27, confirming the specificity of this peptide; Scrambled BMAP-27 did not retain its original conformation, but had the same net charge (+10), indicating that structure is significant to maintaining its antimicrobial activity; has immunomodulatory roles desirable for treatment of infectious disorders; reduces cytotoxicity of mammalian cells and inhibit-LPS induced TNF-α secretion;
Biochemical Properties α-helical bovine myeloid antimicrobial peptides; hydrophobic C-terminal
Significance in milk initial response of the mammary epithelium to microbial infection
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
CATH Matched CATH superfamily
Predicted Disorder Regions 1-6,55-77,89-95,136-151
DisProt Annotation
TM Helix Prediction 1TMH; (13-31)
Significance of PTMs Antimicrobial peptides and upregulated in mastitis
Bibliography 1. Baumann, A., Kiener, M. S., Haigh, B., Perreten, V., and Summerfield, A. (2017) Differential Ability of Bovine Antimicrobial Cathelicidins to Mediate Nucleic Acid Sensing by Epithelial Cells. Front. Immunol. 8, 59.
2. Mookherjee, N., Wilson, H. L., Doria, S., Popowych, Y., Falsafi, R., Yu, J. J., Li, Y., Veatch, S., Roche, F. M., Brown, K. L., Brinkman, F. S. L., Hokamp, K., Potter, A., Babiuk, L. A., Griebel, P. J., and Hancock, R. E. W. (2006) Bovine and human cathelicidin cationic host defense peptides similarly suppress transcriptional responses to bacterial lipopolysaccharide. J. Leukoc. Biol. 80, 1563–1574.
3. Haines, L. R., Thomas, J. M., Jackson, A. M., Eyford, B. A., Razavi, M., Watson, C. N., Gowen, B., Hancock, R. E. W., and Pearson, T. W. (2009) Killing of Trypanosomatid Parasites by a Modified Bovine Host Defense Peptide, BMAP-18. PLoS Negl. Trop. Dis. 3, e373.