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Primary Information | |
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| BoMiProt ID | Bomi126 |
| Protein Name | Cathelicidin-6 |
| Organism | Bos taurus |
| Uniprot ID | P54228 |
| Milk Fraction | Whey |
| Ref Sequence ID | NP_777257.1 |
| Aminoacid Length | 158 |
| Molecular Weight | 17852 |
| FASTA Sequence | Download |
| Gene Name | CATHL6 |
| Gene ID | 317651 |
| Protein Existence Status | Reviewed: Experimental evidence at protein level |
Secondary Information | |
| Protein Function | Scrambled BMAP–27 has reduced antimicrobial action against S. aureus, S. uberis and E. coli compared with unmodified BMAP-27, confirming the specificity of this peptide; Scrambled BMAP-27 did not retain its original conformation, but had the same net charge (+10), indicating that structure is significant to maintaining its antimicrobial activity; has immunomodulatory roles desirable for treatment of infectious disorders; reduces cytotoxicity of mammalian cells and inhibit-LPS induced TNF-α secretion; |
| Biochemical Properties | α-helical bovine myeloid antimicrobial peptides; hydrophobic C-terminal |
| Significance in milk | initial response of the mammary epithelium to microbial infection |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | |
| CATH | Matched CATH superfamily n/a |
| Predicted Disorder Regions | 1-6,55-77,89-95,136-151 |
| DisProt Annotation | |
| TM Helix Prediction | 1TMH; (13-31) |
| Significance of PTMs | Antimicrobial peptides and upregulated in mastitis |
| PDB ID | 2KET, |
| Bibliography | 1. Baumann, A., Kiener, M. S., Haigh, B., Perreten, V., and Summerfield, A. (2017) Differential Ability of Bovine Antimicrobial Cathelicidins to Mediate Nucleic Acid Sensing by Epithelial Cells. Front. Immunol. 8, 59. 2. Mookherjee, N., Wilson, H. L., Doria, S., Popowych, Y., Falsafi, R., Yu, J. J., Li, Y., Veatch, S., Roche, F. M., Brown, K. L., Brinkman, F. S. L., Hokamp, K., Potter, A., Babiuk, L. A., Griebel, P. J., and Hancock, R. E. W. (2006) Bovine and human cathelicidin cationic host defense peptides similarly suppress transcriptional responses to bacterial lipopolysaccharide. J. Leukoc. Biol. 80, 1563–1574. 3. Haines, L. R., Thomas, J. M., Jackson, A. M., Eyford, B. A., Razavi, M., Watson, C. N., Gowen, B., Hancock, R. E. W., and Pearson, T. W. (2009) Killing of Trypanosomatid Parasites by a Modified Bovine Host Defense Peptide, BMAP-18. PLoS Negl. Trop. Dis. 3, e373. |