Primary Information
BoMiProt ID	Bomi122
Protein Name	Serum amyloid A protein
Organism	Bos taurus
Uniprot ID	P35541
Milk Fraction	Whey
Ref Sequence ID	NP_001068728.1
Aminoacid Length	130
Molecular Weight	14516
FASTA Sequence	Download
Gene Name	SAA1
Gene ID	506412
Protein Existence Status	Reviewed: Experimental evidence at protein level
Secondary Information
Protein Function	Acute phase proteins; role in increased cholesterol efflux from macrophages at sites of tissue injury; pro-inflammatory and anti-inflammatory; suggested roles of alkaline SAA is upregulation of mucin expression in newborn calf intestinal mucosa and enhanced mucosal immunity of the newborn
Biochemical Properties	Presence of multiple highly alkaline isoforms in bovine milk
Significance in milk	markers of subclinical inflammation in ruminants; two acidic serum SAA isoforms (pI 5.5 and 4.5) in the subclinical mastitis;
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation
Predicted Disorder Regions	55-73,80-130
DisProt Annotation
TM Helix Prediction	No TM helices
Bibliography	1. Kovačević-Filipović, M., Ilić, V., Vujčić, Z., Dojnov, B., Stevanov-Pavlović, M., Mijačević, Z., and Božić, T. (2012) Serum amyloid A isoforms in serum and milk from cows with Staphylococcus aureus subclinical mastitis. Vet. Immunol. Immunopathol. 145, 120–128. 2. Cabana, V. G., Siegel, J. N., and Sabesin, S. M. (1989) Effects of the acute phase response on the concentration and density distribution of plasma lipids and apolipoproteins. J. Lipid Res. 30, 39–49. 3. Uhlar, C. M. and Whitehead, A. S. (1999) Serum amyloid A, the major vertebrate acute-phase reactant. Eur. J. Biochem. 265, 501–523. 4. Eckersall, P. D., Young, F. J., McComb, C., Hogarth, C. J., Safi, S., Weber, A., McDonald, T., Nolan, A. M., and Fitzpatrick, J. L. (2001) Acute phase proteins in serum and milk from dairy cows with clinical mastitis. Vet. Rec. 148, 35–41. 5. Jacobsen, S., Andersen, P. H., Toelboell, T., and Heegaard, P. M. H. (2004) Dose Dependency and Individual Variability of the Lipopolysaccharide-Induced Bovine Acute Phase Protein Response. J. Dairy Sci. 87, 3330–3339. 6. McDonald, T. L., Larson, M. A., Mack, D. R., and Weber, A. (2001) Elevated extrahepatic expression and secretion of mammary-associated serum amyloid A 3 (M-SAA3) into colostrum. Vet. Immunol. Immunopathol. 83, 203–211.