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Primary Information | |
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| BoMiProt ID | Bomi118 |
| Protein Name | Spermadhesin-1 |
| Organism | Bos taurus |
| Uniprot ID | P29392 |
| Milk Fraction | Whey |
| Ref Sequence ID | NP_777041.1 |
| Aminoacid Length | 134 |
| Molecular Weight | 15036 |
| FASTA Sequence | Download |
| Gene Name | SPADH1 |
| Gene ID | 282373 |
| Protein Existence Status | Reviewed: Experimental evidence at protein level |
Secondary Information | |
| Presence in other biological fluids/tissue/cells | male genital tract of pig, horse and bulls, seminal vescicles, peripherally associated to the sperm surface, |
| Protein Function | multifunctional proteins; involved in different steps of fertilization; represent a novel class of lectins that may be involved in sequential steps of fertilization; stimulates progesterone secretion and growth through cell division and in bovine granulosa cells in vitro |
| Biochemical Properties | belong to the superfamily of proteins with a CUB domain with a predicted all-p structure; |
| Significance in milk | potential protein candidate biomarkers of bovine pregnancy; |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | |
| SCOP | Class : All beta proteins Fold : CUB-like Superfamily : Spermadhesin, CUB domain Family : spermadhesin, cub domain Domain Name : 1SFP A:4-114 |
| CATH | Matched CATH superfamily 2.60.120.290 |
| Predicted Disorder Regions | NA |
| DisProt Annotation | |
| TM Helix Prediction | No TM helices |
| PDB ID | 1SFP, |
| Bibliography | 1. Johnston, D., Malo Estepa, I., Ebhardt, H. A., Crowe, M. A., & Diskin, M. G. (2018). Differences in the bovine milk whey proteome between early pregnancy and the estrous cycle. Theriogenology, 114, 301–307. https://doi.org/10.1016/j.theriogenology.2018.04.008. 2. Einspanier, R., Krause, I., Calvete, J. J., Töfper-Petersen, E., Klostermeyer, H., & Karg, H. (1994). Bovine seminal plasma aSFP: localization of disulfide bridges and detection of three different isoelectric forms. FEBS Letters, 344(1), 61–64. https://doi.org/10.1016/0014-5793(94)00362-9. 3. Romero, A., Romão, M. J., Varela, P. F., Kölln, I., Dias, J. M., Carvalho, A. L., … Calvete, J. J. (1997). The crystal structures of two spermadhesins reveal the CUB domain fold. Nature Structural Biology, 4(10), 783–788. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/9334740. |