Search by BoMiProt ID - Bomi118

Primary Information

BoMiProt ID Bomi118
Protein Name Spermadhesin-1
Organism Bos taurus
Uniprot IDP29392
Milk FractionWhey
Ref Sequence ID NP_777041.1
Aminoacid Length 134
Molecular Weight 15036
FASTA Sequence Download
Gene Name SPADH1
Gene ID 282373
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondary Information

Presence in other biological fluids/tissue/cells male genital tract of pig, horse and bulls, seminal vescicles, peripherally associated to the sperm surface,
Protein Function multifunctional proteins; involved in different steps of fertilization; represent a novel class of lectins that may be involved in sequential steps of fertilization; stimulates progesterone secretion and growth through cell division and in bovine granulosa cells in vitro
Biochemical Properties belong to the superfamily of proteins with a CUB domain with a predicted all-p structure;
Significance in milk potential protein candidate biomarkers of bovine pregnancy;
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
SCOP Class : All beta proteins
Fold : CUB-like
Superfamily : Spermadhesin, CUB domain
Family : spermadhesin, cub domain
Domain Name : 1SFP A:4-114

CATH Matched CATH superfamily
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1. Johnston, D., Malo Estepa, I., Ebhardt, H. A., Crowe, M. A., & Diskin, M. G. (2018). Differences in the bovine milk whey proteome between early pregnancy and the estrous cycle. Theriogenology, 114, 301–307.
2. Einspanier, R., Krause, I., Calvete, J. J., Töfper-Petersen, E., Klostermeyer, H., & Karg, H. (1994). Bovine seminal plasma aSFP: localization of disulfide bridges and detection of three different isoelectric forms. FEBS Letters, 344(1), 61–64.
3. Romero, A., Romão, M. J., Varela, P. F., Kölln, I., Dias, J. M., Carvalho, A. L., … Calvete, J. J. (1997). The crystal structures of two spermadhesins reveal the CUB domain fold. Nature Structural Biology, 4(10), 783–788. Retrieved from