Search by BoMiProt ID - Bomi11

Primary Information

BoMiProt ID Bomi11
Protein Name Cathelicidin-2
Organism Bos taurus
Uniprot IDP19660
Milk FractionWhey
Ref Sequence ID NP_777251.1
Aminoacid Length 176
Molecular Weight 20030
FASTA Sequence Download
Gene Name CATHL2
Gene ID 282165
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondary Information

Presence in other biological fluids/tissue/cells bovine neutrophil
Protein Function almost exclusively active against Gram-negative bacteria; non-lytic and is efficiently internalized by bacterial cells without membrane disruption, enabling access to intracellular targets
Biochemical Properties proline-rich peptides; positively charged peptides and make up 4% of total neutrophil proteins; hydrophobic peptide with charge +10;
Significance in milk initial response of the mammary epithelium to microbial infection
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 1-7,63-77,82-94,139-150,173-176
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Antimicrobial peptides and upregulated in mastitis
Additional Comments pig leukocyte protein named cathelin shared similar size and higher than70% sequence identity to bovine cathelicidin 2
Bibliography 1. Smith, W. L., Sunaga, O., and Cullor, J. S. (1999) An evaluation of the tissue expression of a bovine dodecapeptide bactenecin in the adult and fetal animal. Comp. Haematol. Int. 9, 132–138.
2. 1. Tomasinsig, L., Scocchi, M., Di Loreto, C., Artico, D., and Zanetti, M. (2002) Inducible expression of an antimicrobial peptide of the innate immunity in polymorphonuclear leukocytes. J. Leukoc. Biol. 72, 1003–1010