Primary Information |
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| BoMiProt ID | Bomi11 |
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| Protein Name | Cathelicidin-2 |
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| Organism | Bos taurus |
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| Uniprot ID | P19660 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_777251.1 |
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| Aminoacid Length | 176 |
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| Molecular Weight | 20030 |
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| FASTA Sequence |
Download |
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| Gene Name | CATHL2 |
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| Gene ID | 282165 |
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| Protein Existence Status | Reviewed: Experimental evidence at protein level |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | bovine neutrophil |
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| Protein Function | almost exclusively
active against Gram-negative bacteria; non-lytic and is efficiently internalized by bacterial cells without
membrane disruption, enabling access to intracellular targets |
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| Biochemical Properties | proline-rich peptides; positively charged
peptides and make up 4% of total neutrophil proteins; hydrophobic peptide with charge +10; |
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| Significance in milk | initial response of the mammary epithelium to microbial infection |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | 1-7,63-77,82-94,139-150,173-176 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Antimicrobial peptides and upregulated in mastitis |
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| Additional Comments | pig leukocyte protein named cathelin shared similar
size and higher than70% sequence
identity to bovine cathelicidin 2 |
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| Bibliography | 1. Smith, W. L., Sunaga, O., and Cullor, J. S. (1999) An evaluation of the tissue expression of a bovine dodecapeptide bactenecin in the adult and fetal animal. Comp. Haematol. Int. 9, 132–138.
2. 1. Tomasinsig, L., Scocchi, M., Di Loreto, C., Artico, D., and Zanetti, M. (2002) Inducible expression of an antimicrobial peptide of the innate immunity in polymorphonuclear leukocytes. J. Leukoc. Biol. 72, 1003–1010 |
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