Search by BoMiProt ID - Bomi109

Primary Information

BoMiProt ID Bomi109
Protein Name Angiogenin1
Organism Bos taurus
Uniprot IDP10152
Milk FractionWhey
Aminoacid Length 148
Molecular Weight 16970
FASTA Sequence Download
Gene Name ANG1
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondary Information

Presence in other biological fluids/tissue/cells liver, placenta, epthelial cells, fibroblasts, blood cells, serum
Protein Function Active inductor of vessel growth; maintenance of homeostasis in living organisms; regulates immune system
Biochemical Properties Homologous to bovine pancreatic RNase A (34% identity) and the three major active site residues known to be involved in the catalytic process, His‐14, Lys‐41 and His‐115, are conserved; contains the cell recognition tripeptide Arg‐Gly‐Asp.
Significance in milk Induced production of cytokines in leukocytes;
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
SCOP Class : Alpha and beta proteins (a+b)
Fold : RNase A-like
Superfamily : RNase A-like
Family : Ribonuclease A-like
Domain Name : 1AGI A:1-125

CATH Matched CATH superfamily
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction 1TMH ; (4-22)
Bibliography 1. Maes, P., Damart, D., Rommens, C., Montreuil, J., Spik, G., & Tartar, A. (1988). The complete amino acid sequence of bovine milk angiogenin. FEBS Letters, 241(1–2), 41–45.
2. Shcheglovitova, O. N., Maksyanina, E. V., Ionova, I. I., Rustam’yan, Y. L., & Komolova, G. S. (2003). Cow milk angiogenin induces cytokine production in human blood leukocytes. Bulletin of Experimental Biology and Medicine, 135(2), 158–160.