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Primary Information | |
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| BoMiProt ID | Bomi109 |
| Protein Name | Angiogenin1 |
| Organism | Bos taurus |
| Uniprot ID | P10152 |
| Milk Fraction | Whey |
| Aminoacid Length | 148 |
| Molecular Weight | 16970 |
| FASTA Sequence | Download |
| Gene Name | ANG1 |
| Protein Existence Status | Reviewed: Experimental evidence at protein level |
Secondary Information | |
| Presence in other biological fluids/tissue/cells | liver, placenta, epthelial cells, fibroblasts, blood cells, serum |
| Protein Function | Active inductor of vessel growth; maintenance of homeostasis in living organisms; regulates immune system |
| Biochemical Properties | Homologous to bovine pancreatic RNase A (34% identity) and the three major active site residues known to be involved in the catalytic process, His‐14, Lys‐41 and His‐115, are conserved; contains the cell recognition tripeptide Arg‐Gly‐Asp. |
| Significance in milk | Induced production of cytokines in leukocytes; |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | |
| SCOP | Class : Alpha and beta proteins (a+b) Fold : RNase A-like Superfamily : RNase A-like Family : Ribonuclease A-like Domain Name : 1AGI A:1-125 |
| CATH | Matched CATH superfamily 3.10.130.10 |
| Predicted Disorder Regions | NA |
| DisProt Annotation | |
| TM Helix Prediction | 1TMH ; (4-22) |
| PDB ID | 1AGI, 1GIO, |
| Bibliography | 1. Maes, P., Damart, D., Rommens, C., Montreuil, J., Spik, G., & Tartar, A. (1988). The complete amino acid sequence of bovine milk angiogenin. FEBS Letters, 241(1–2), 41–45. https://doi.org/10.1016/0014-5793(88)81027-5. 2. Shcheglovitova, O. N., Maksyanina, E. V., Ionova, I. I., Rustam’yan, Y. L., & Komolova, G. S. (2003). Cow milk angiogenin induces cytokine production in human blood leukocytes. Bulletin of Experimental Biology and Medicine, 135(2), 158–160. https://doi.org/10.1023/A:1023871931764. |