Search by BoMiProt ID - Bomi10802


Primary Information

BoMiProt ID Bomi10802
Protein Name Zinc-binding alcohol dehydrogenase domain-containing protein 2
Organism Bos taurus
Uniprot IDQ24K16
Milk FractionWhey,MFGM
Ref Sequence ID NP_001069432.1
Aminoacid Length 377
Molecular Weight 40119
FASTA Sequence Download
Gene Name ZADH2
Gene ID 532505
Protein Existence Status reviewed

Secondary Information

Protein Function Negatively regulates adipogenesis through regulation of PPARγ activity.PTGR-3 decreases proadipogenic effect of 15-keto-PGE2 through regulation of PPARγ activity.PTGR-3 may play a role in maintaining the undifferentiated state in preadipocytes.
Biochemical Properties is a 15-oxoprostaglandin-Δ13-reductase.15-keto-PGE2 can be metabolized to 13,14-dihydro-15-keto-PGE2 by PTGR-3 in a NADPH-dependent reaction and that this reaction was linearly accelerated with increased concentration of PTGR-3 recombinant protein.PTGR-3 is able to catalyze the metabolism of other prostaglandins, including 15-keto-PGF2α, 15-keto-PGF1α, and 15-keto-PGEPTGR-3 is able to catalyze the metabolism of other prostaglandins, including 15-keto-PGF2α, 15-keto-PGF1α, and 15-keto-PGE1.PTGR-3 had the highest efficiency for 15-keto-PGF2α catabolic reaction (Kcat/Km= 271.76 ± 8.82 mM−1 min−1 compared with 15-keto-PGF1α (214.41 ± 12.92 mM−1 min−1), 15-keto-PGE2 (157.24 ± 14.00 mM−1 min−1) and 15-keto-PGE1 (58.45 ± 4.59 mM−1 min−1).
PTMs Acetylation on Lys, Phosphorylation on Ser
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|Q24K16|PTGR3_BOVIN Prostaglandin reductase-3 OS=Bos taurus OX=9913 GN=ZADH2 PE=2 SV=1 MQRLALAGTRAIVDMSYARHFLDFQGSAIPSKMQKLVVTRLSPNFREAVTLRRDCPVPLP GDGDLLVRNRFVGVNASDINYSAGRYDPSVKTPFDAGFEGVGEVVALGLSASAAFMVGQA VAYMAPGSFAEYTVVPARVAIPVPGLKPEYLTLLVSGTTAYISLKELGGLSEGKKVLVTA AAGGTGQFAVQLAKKAKCHVIGTCSSAEKSAFLKSVGCDRPINYNTEHVGTVLRQEYPQG VDVVYESVGGAMFDLAVDALATRGRLIVIGFVSGYQTPTGLSPVKAGTLPAKLLKKSAS*299V QGFFLNHYLPEFRGAMDHLLKMYAGGELVCEVDTGGLSAEGRFTGLESVFRAVDYMYMRK NTGKIVVELPPSVNSKL
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments PTGR-3 protein may facilitate maintaining the undifferentiated state in preadipocytes by inhibiting endogenous 15-keto-PGE2 production and that suppression of PTGR-3 expression is required for normal adipocyte differentiation by regulating PPARγ transcriptional activity.PTGR-3 expression is reduced in adipose tissue from murine models of obesity. Modulation of PTGR-3 expression or activity might provide a novel avenue in treating obesity and related metabolic disorders.
Bibliography Yu YH, Chang YC, Su TH, Nong JY, Li CC, Chuang LM. Prostaglandin reductase-3 negatively modulates adipogenesis through regulation of PPARγ activity. J Lipid Res. 2013 Sep;54(9):2391-9. doi: 10.1194/jlr.M037556. Epub 2013 Jul 2. PMID: 23821743; PMCID: PMC3735937.