Primary Information |
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| BoMiProt ID | Bomi10801 |
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| Protein Name | Zinc transporter ZIP13/Solute carrier family 39 member 13/Zrt- and Irt-like protein 13 |
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| Organism | Bos taurus |
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| Uniprot ID | A5D7H1 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001091601.1 |
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| Aminoacid Length | 423 |
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| Molecular Weight | 44432 |
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| FASTA Sequence |
Download |
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| Gene Name | SLC39A13/ZIP13 |
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| Gene ID | 614946 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Zn2+ homeostasis and adipocyte biogenesis |
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| Biochemical Properties | ZIP13 contains eight putative transmembrane domains and a unique hydrophilic region and that it resides with both its N and C termini facing the luminal side on the Golgi. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | 137-143, 176-189, 330-365 |
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| DisProt Annotation | |
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| TM Helix Prediction | 5TMHs; (67-89),(110-132),(151-169),(371-389) and (404-422) |
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| Additional Comments | ZIP13 is downregulated at reperfusion in mouse hearts |
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| Bibliography | Wang J, Cheng X, Zhao H, Yang Q, Xu Z. Downregulation of the zinc transporter SLC39A13 (ZIP13) is responsible for the activation of CaMKII at reperfusion and leads to myocardial ischemia/reperfusion injury in mouse hearts. J Mol Cell Cardiol. 2021 Mar;152:69-79. doi: 10.1016/j.yjmcc.2020.12.002. Epub 2020 Dec 9. PMID: 33307093. |
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