Primary Information |
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| BoMiProt ID | Bomi10800 |
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| Protein Name | Zinc transporter ZIP11/Solute carrier family 39 member 11
Zrt- and Irt-like protein 11/ZIP-11 |
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| Organism | Bos taurus |
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| Uniprot ID | Q2YDD4 |
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| Milk Fraction | Whey,exosome |
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| Ref Sequence ID | NP_001069858.1 |
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| Aminoacid Length | 341 |
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| Molecular Weight | 35198 |
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| FASTA Sequence |
Download |
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| Gene Name | SLC39A11 |
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| Gene ID | 615681 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | cellular zinc transporter.absorption and metabolism of dietary zinc. |
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| Biochemical Properties | ZIP11 has 6 transmembrane domains with the N terminus having an extracellular location . histidine-rich loop is usually found in Zip transporter proteins |
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| Significance in milk | Human milk contains less zinc than does bovine milk, with zinc concentrations of both decreasing throughout lactation.Lowering the pH further decreased zinc bioavailability from human milk, but not from cow's milk. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | 1 disordered segment; (150-186) |
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| DisProt Annotation | |
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| TM Helix Prediction | 5TMHs; (15-33),(46-64),(73-95),(193-215) and (274-296) |
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| Additional Comments | when dietary zinc intake is compromised, the colon may increase zinc transporter expression to improve the efficiency for absorption via increased expression of specific zinc transporters, including ZIP11 and also zinc transporter Slc39a4 |
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| Bibliography | Martin AB, Aydemir TB, Guthrie GJ, Samuelson DA, Chang SM, Cousins RJ. Gastric and colonic zinc transporter ZIP11 (Slc39a11) in mice responds to dietary zinc and exhibits nuclear localization. J Nutr. 2013 Dec;143(12):1882-8. doi: 10.3945/jn.113.184457. Epub 2013 Oct 2. PMID: 24089422; PMCID: PMC3827636. |
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