Primary Information |
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| BoMiProt ID | Bomi10787 |
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| Protein Name | Zinc finger protein AEBP2/Adipocyte enhancer-binding protein 2/AE-binding protein 2 |
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| Organism | Bos taurus |
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| Uniprot ID | A4FV57 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001076954.2 |
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| Aminoacid Length | 511 |
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| Molecular Weight | 54049 |
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| FASTA Sequence |
Download |
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| Gene Name | AEBP2 |
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| Gene ID | 537791 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | AEBP2 is a zinc finger protein that has been shown to interact with the mammalian Polycomb Repression Complex 2 (PRC2).Plays a role in nucleosome localization of the PRC2 complex. |
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| Biochemical Properties | These isoforms show developmental stage-specific expression patterns: the adult-specific larger form (51 kDa) and the embryo-specific smaller form (32 kDa).AEBP2 binds to a consensus sequence with bipartite structure, CTT(N)15-23cagGCC, and this binding is mainly driven by the three zinc finger units.the mammalian AEBP2 sequences can be divided into six protein domains: acidic, neutral, serine-rich, zinc finger, basic and lysine-rich domains. Among these six domains, two domains (zinc finger and basic). |
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| PTMs | Acetylation on Ala, Phosphorylation on Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A4FV57|AEBP2_BOVIN Zinc finger protein AEBP2 OS=Bos taurus OX=9913 GN=AEBP2 PE=2 SV=2
MAAALTDMADLEELSRLS*18PLPPGS*24PGPAARGRAEPPEEEEEEDEEEEAEAEAVAALLLNG
GGGGGGVGGGEAETMSEPSPESASQAGEDDDEEEDDDEEEEDESSSGGGEEESSAESLVG
SSSGGSSSDETRSLS*135PGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGD
EGYGTGGGGSSATSGGRRGS*200LEMS*204S*205DGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMM
NGQGSTTSSSKNIAYNCCWDQCQACFTSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYN
TPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPK
AKEESPSKAGMNKRRKLKNKRRRS*384LPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGH
SVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTAL
LLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ
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| Predicted Disorder Regions | 5-249, 348-351, 362-372 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Kim H, Kang K, Kim J. AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2. Nucleic Acids Res. 2009 May;37(9):2940-50. doi: 10.1093/nar/gkp149. Epub 2009 Mar 17. PMID: 19293275; PMCID: PMC2685092. |
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