Primary Information |
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BoMiProt ID | Bomi10782 |
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Protein Name | Zinc finger protein 750 |
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Organism | Bos taurus |
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Uniprot ID | A2VDR9 |
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Milk Fraction | Whey |
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Ref Sequence ID | NP_001075002.1 |
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Aminoacid Length | 703 |
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Molecular Weight | 75167 |
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FASTA Sequence |
Download |
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Gene Name | ZNF750 |
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Gene ID | 535628 |
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Protein Existence Status | reviewed |
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Secondary Information |
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Protein Function | A transcription factor regulated by p63,plays a critical role in epithelial tissues homoeostasis |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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Predicted Disorder Regions | 86-101, 410-421, 456-462, 495-524, 549-649 |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Additional Comments | upregulation of ZNF750 inhibited the expression of b-catenin and the downstream targets (cyclin D1, c-Myc, Bcl-2, MMP2 and MMP9), indicating it could block the activation of Wnt/b-catenin pathway. |
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Bibliography | Butera A, Cassandri M, Rugolo F, Agostini M, Melino G. The ZNF750-RAC1 axis as potential prognostic factor for breast cancer. Cell Death Discov. 2020 Nov 29;6(1):135. doi: 10.1038/s41420-020-00371-2. PMID: 33298895; PMCID: PMC7701147. |