Primary Information |
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| BoMiProt ID | Bomi10781 |
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| Protein Name | Zinc finger protein 746 |
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| Organism | Bos taurus |
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| Uniprot ID | Q3B7M4 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001030418.1 |
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| Aminoacid Length | 630 |
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| Molecular Weight | 67972 |
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| FASTA Sequence |
Download |
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| Gene Name | ZNF746 |
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| Gene ID | 521998 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | promotes colorectal cancer progression via c-Myc stability mediated by glycogen synthase kinase 3β and F-box and WD repeat domain-containing 7. |
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| Biochemical Properties | ZNF746 is normally degraded through UPS by parkin activation, as ZNF746 is a substrate of the ubiquitin E3 ligase parkin [ |
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| PTMs | Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | ZNF746 was overexpressed in HCT116, SW620, and SW480 cells, which was supported by CRC tissue microarray and TCGA analysis. |
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| Bibliography | Jung JH, Jung DB, Kim H, Lee H, Kang SE, Srivastava SK, Yun M, Kim SH. Zinc finger protein 746 promotes colorectal cancer progression via c-Myc stability mediated by glycogen synthase kinase 3β and F-box and WD repeat domain-containing 7. Oncogene. 2018 Jul;37(27):3715-3728. doi: 10.1038/s41388-018-0225-0. Epub 2018 Apr 9. PMID: 29628506. |
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