Primary Information
BoMiProt ID	Bomi10776
Protein Name	Zinc finger protein 692/AICAR responsive element binding protein
Organism	Bos taurus
Uniprot ID	A0JNJ4
Milk Fraction	Whey
Ref Sequence ID	NP_001019667.2
Aminoacid Length	510
Molecular Weight	55474
FASTA Sequence	Download
Gene Name	ZNF692/AREBP
Gene ID	507847
Protein Existence Status	reviewed
Secondary Information
Protein Function	It may act as an transcriptional repressor for PCK1 gene expression. It may also be involved in AMPK signaling pathway for regulation of hepatic gluconeogenesis.
PTMs	Phosphorylation
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	>sp|A0JNJ4|ZN692_BOVIN Zinc finger protein 692 OS=Bos taurus OX=9913 GN=ZNF692 PE=2 SV=1 MAASPADASRRRREKRRQLDARRSKCRIRLGGHMEQWCLLKEQLGFSLHSQLAKFLLDRY TSSGCVLCAGPEPVAPKGLQYLVLLSHAHSRECSLVPGLRGPGGQDGGLVWECSAGHTFS WGPSSGPKSPEEPNLTPLPSTDERSWCPEAKSGQEPAGLES*161NCDERAQEARMPRGAGPPP ETFPSLGEDGEEEEEDEEEMLSDASPWTYSSSPDDEPDVPKPPPS*225PVTHALKDGEIAPAP AAVPAPLASPSSSASSLGSGAPGPVEVRIQPELRGTPQADQQTEPLASPGSQAQSALASA WDEDTAQIGPKRIRKAAKRELLPCDFPGCGRIFSNRQYLNHHKKYQHIHQKSFSCPEPAC GKSFNFKKHLKEHVKLHSDTRDYICEFCARSFRTSSNLVIHRRIHTGEKPLQCEICGFTC RQKASLNWHRRKHAETVAALRFPCEFCGKRFEKPDSVAAHRSKS*464HPALLLAPQELSGPVE SCSSILASASLGASEGSRSTLAPQAPILLP
Predicted Disorder Regions	(1-19), (94-104), (119-250), (260-300)
DisProt Annotation
TM Helix Prediction	No TM helices
Significance of PTMs	Phosphorylation at Ser-464 results in loss of DNA-binding activity.
Bibliography	Xing, Y., Ren, S., Ai, L., Sun, W., Zhao, Z., Jiang, F., Zhu, Y., & Piao, D. (2019). ZNF692 promotes colon adenocarcinoma cell growth and metastasis by activating the PI3K/AKT pathway. International journal of oncology, 54(5), 1691–1703. https://doi.org/10.3892/ijo.2019.4733