Primary Information |
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| BoMiProt ID | Bomi10774 |
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| Protein Name | Zinc finger protein 668 |
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| Organism | Bos taurus |
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| Uniprot ID | Q2TA17 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001070421.1 |
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| Aminoacid Length | 619 |
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| Molecular Weight | 68095 |
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| FASTA Sequence |
Download |
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| Gene Name | ZNF668 |
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| Gene ID | 767831 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | suppresses non-small cell lung cancer invasion and migration by downregulating Snail and upregulating E-cadherin and zonula occludens-1 |
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| Biochemical Properties | ZNF668 has been demonstrated to mediate Tip60 acetylation and ionizing radiation-induced hyperacetylation of H2A histone family member X following DNA damage |
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| Significance in milk | ZNF668 has been demonstrated to mediate Tip60 acetylation and ionizing radiation-induced hyperacetylation of H2A histone family member X following DNA damage |
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| PTMs | Acetylation and phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q2TA17|ZN668_BOVIN Zinc finger protein 668 OS=Bos taurus OX=9913 GN=ZNF668 PE=2 SV=2
MEVESPEERS*10PAPGYKRSGRRYKCLSCTKTFPNAPRAARHAATHGLADCTEEMAEAKLKP
ETDPKAEDASGDKVSGAAAKPRPYACPLCPKAYKTAPELRSHGRSHTGEKPFPCPECGRR
FMQPVCLRVHLASHAGELPFRCAHCPKAYGALSKLKIHQRGHTGERPYTCADCGKSFADP
SVFRKHRRTHAGLRPYSCERCGKAYAELKDLRNHERSHTGERPFLCSECGKSFSRSSSLT
CHQRIHAAQKPYRCPACGKGFTQLSSYQSHERTHSGEKPFLCPRCGRMFSDPSSFRRHQR
AHEGVKPYRCEKCGKDFRQPADLAMHRRVHTGDRPFKCLQCDKTFVASWDLKRHALVHSG
QRPFRCEECGRAFAERASLTKHSRVHSGERPFHCNACGKSFVVSSSLRKHERTHRSSEAT
GAPPQQELVVGLALPVSMAGEGPAAPASGAALGDPPAGLLGLPSESGGVMATQWQVVGMT
VEHVECQDAGVGEAPGPLGAAGEVGGEEVDEKPPQFVCRECKETFSTLTLLRRHERSHPE
LRPFHCTQCGKSFSDRAGLRKHSRTHSSVRPYTCPHCPKAFLSASDLRKHERTHPVPIGT
PTPLEPLVALLGMPEEGPA |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | 1.Hu R, Wang E, Peng G, Dai H and Lin SY: Zinc finger protein 668 interacts with Tip60 to promote H2AX acetylation after DNA damage. Cell Cycle. 12:2033–41. 2013. View Article : Google Scholar : PubMed/NCBI 2.Zhang X, Jiang G, Wu J, Zhou H, Zhang Y, Miao Y, Feng Y, Yu J. Zinc finger protein 668 suppresses non-small cell lung cancer invasion and migration by downregulating Snail and upregulating E-cadherin and zonula occludens-1. Oncol Lett. 2018 Mar;15(3):3806-3813. doi: 10.3892/ol.2018.7802. Epub 2018 Jan 16. PMID: 29556277; PMCID: PMC5844101. |
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