Search by BoMiProt ID - Bomi10746

Primary Information

BoMiProt ID Bomi10746
Protein Name Zinc finger protein 414
Organism Bos taurus
Uniprot IDQ32KV8
Milk FractionWhey
Ref Sequence ID NP_001033264.1
Aminoacid Length 391
Molecular Weight 41094
FASTA Sequence Download
Gene Name ZNF414
Gene ID 538455
Protein Existence Status reviewed

Secondary Information

Protein Function Predicted to be involved in regulation of transcription by RNA polymerase II.
Biochemical Properties Sp1 contains three zinc finger motifs — as in Zif268, each carries a single α-helix that invades the major groove and makes base-specific contacts. Examination of the structure of a three-finger Cys2-His2 ZFP bound to DNA shows an uninterrupted run of 9 bp that is contacted by the protein viewed edge-on, the protein can be seen as engaging a full 360° of the helix.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 1-110, 201-239, 279-288, 296-310, 349-353, 381-390
DisProt Annotation
TM Helix Prediction no TM helices
Additional Comments ZFP transcription factors as a model system to compare in vitro binding to chromatin by transcription factors with their in vivo behavior in gene regulation.
Bibliography Urnov FD. A feel for the template: zinc finger protein transcription factors and chromatin. Biochem Cell Biol. 2002;80(3):321-33. doi: 10.1139/o02-084. PMID: 12123285.