Primary Information |
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| BoMiProt ID | Bomi10746 |
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| Protein Name | Zinc finger protein 414 |
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| Organism | Bos taurus |
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| Uniprot ID | Q32KV8 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001033264.1 |
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| Aminoacid Length | 391 |
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| Molecular Weight | 41094 |
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| FASTA Sequence |
Download |
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| Gene Name | ZNF414 |
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| Gene ID | 538455 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Predicted to be involved in regulation of transcription by RNA polymerase II. |
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| Biochemical Properties | Sp1 contains three zinc finger motifs — as in Zif268, each carries a single α-helix that invades the major groove and makes base-specific contacts. Examination of the structure of a three-finger Cys2-His2 ZFP bound to DNA shows an uninterrupted run of 9 bp that is contacted by the protein viewed edge-on, the protein can be seen as engaging a full 360° of the helix. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | 1-110, 201-239, 279-288, 296-310, 349-353, 381-390 |
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| DisProt Annotation | |
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| TM Helix Prediction | no TM helices |
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| Additional Comments | ZFP transcription factors as a model system to compare in vitro binding to chromatin by transcription factors with their in vivo behavior in gene regulation. |
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| Bibliography | Urnov FD. A feel for the template: zinc finger protein transcription factors and chromatin. Biochem Cell Biol. 2002;80(3):321-33. doi: 10.1139/o02-084. PMID: 12123285. |
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