Primary Information |
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| BoMiProt ID | Bomi10742 |
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| Protein Name | Zinc finger protein 397 |
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| Organism | Bos taurus |
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| Uniprot ID | Q1LZ87 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001068730.1 |
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| Aminoacid Length | 534 |
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| Molecular Weight | 61277 |
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| FASTA Sequence |
Download |
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| Gene Name | ZNF397 |
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| Gene ID | 506448 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | ZNF397 is a transcription factor that plays a role in the regulation of transcription at the centromere. |
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| Biochemical Properties | belongs to the classical Cys(2)His(2) group of the zinc-finger protein superfamily and contains two conserved domains: a leucine-rich SCAN domain and nine Cys(2)His(2) zinc fingers.The SCAN plus linker domain is required for centromere localisation.The SCAN domain is a highly conserved 84-residue motif found near the N-terminus of a subfamily of C2H2 zinc-finger proteins that mediates protein–protein interaction. |
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| PTMs | Isopeptide bond formation, Phosphorylation, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q1LZ87|ZN397_BOVIN Zinc finger protein 397 OS=Bos taurus OX=9913 GN=ZNF397 PE=2 SV=1
MAVESRAVSTPVPQNSQEQELILVKVEESRS*31WGQKLKQSGSARSCQELFRQQFRKFCYQE
TPGPREALGRLQELCYQWLRPELHTKEQILELLVLEQFLSILPEELQIWVQQHSPKNGEE
AVTLLEDLEREFDDPGQQVPATPQGPPMPWKDLTCLGAAQEFTHIQRQPLKKQLKPWEPC
LPPKSGCENNESAIKKDISGEKSQRLSQEPSFGGFSEHKSSLEWQQGSAPGETLRRSPSQ
RASFSPVIFTHKLLANRDHPEPQRNLILSTNSVTYQKVPTEERPYRCDICGHSFKQHSSL
TQHQRIHTGEKPYKCNQCGKAFSLRSYLIIHQRIHSGEKAYECSECGKAFNQSSALIRHR
KIHTGEKACKCNECGKAFSQSSYLIIHQRIHTGEKPYECNECGKTFSQSSKLIRHQRIHT
GERPYECNECGKAFRQSSELITHQRIHSGEKPYECNECGKAFSLSSNLIRHQRIHSGEEP
YQCNECGKTFKRSSALVQHQRIHSGEEAYICSECGKAFRHRSVLTRHQRVHTVK
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | Zfp397 null mice appear phenotypically normal. The nulls are fertile and generate normal litter size and Mendelian ratios of offspring |
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| Bibliography | Bailey SL, Chang SC, Griffiths B, Graham AN, Saffery R, Earle E, Choo KH, Kalitsis P. ZNF397, a new class of interphase to early prophase-specific, SCAN-zinc-finger, mammalian centromere protein. Chromosoma. 2008 Aug;117(4):367-80. doi: 10.1007/s00412-008-0155-7. Epub 2008 Mar 28. PMID: 18369653. |
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