Primary Information |
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BoMiProt ID | Bomi10713 |
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Protein Name | Zinc finger protein 148/Transcription factor ZBP-89/Zinc finger DNA-binding protein 89 |
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Organism | Bos taurus |
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Uniprot ID | Q3Y4E1 |
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Milk Fraction | Whey |
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Ref Sequence ID | NP_001028293.1 |
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Aminoacid Length | 794 |
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Molecular Weight | 89003 |
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FASTA Sequence |
Download |
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Gene Name | ZNF148/ZBP89 |
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Gene ID | 613265 |
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Protein Existence Status | reviewed |
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Secondary Information |
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Protein Function | transcriptional regulation,negative role in human muscle cell differentiation. |
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Biochemical Properties | contains Zinc finger region.C2H2-type 1,C2H2-type 2,C2H2-type 3,C2H2-type 4 involved in DNA binding and metal binding. |
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PTMs | Acetylation, Isopeptide bond formation, Phosphorylation, Ubl conjugation,Sumoylation on K356 |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q3Y4E1|ZN148_BOVIN Zinc finger protein 148 OS=Bos taurus OX=9913 GN=ZNF148 PE=2 SV=1
MNIDDKLEGLFLKCGGIDEMQSSRAMVVMGGVSGQSTVSGELQESVLQDRS*51MPHQEILAA
DEVLQESEMRQQDMISHDELMVHEETVKNDEEQMETHERLPQGLQYALNVPISVKQEITF
TDVSEQLMRDKKQIREPVDLQKKKKRKQRSPAKILTINEDGSLGLKTPKSHVCEHCNAAF
RTNYHLQRHVFIHT*194GEKPFQCSQCDMRFIQKYLLQRHEKIHTGEKPFRCDECGMRFIQKY
HMERHKRTHS*250GEKPYQCEYCLQYFSRTDRVLKHKRMCHENHDKKLNRCAIKGGLLTSEED
S*301GFSTS*306PKDNSLPKKKRQKTEKKSSGMDKESSLDKSDLKKDKNDYLPLYSSSTKVKDEYM
VAEYAVEMPHSSVGGSHLEDASGEIHPPKLVLKKINSKRSLKQPLEQNQTIS*412PLSTYEES
KVSKYAFELVDKQALLDSEGNADIDQVDNLQEGPSKPVHSSTNYDDAMQFLKKKRYLQAA
SNNSREYALNVGTIASQPSVTQAAVASVIDESTTASILDSQALNVEIKSNHDKNVIPDEV
LQTLLDHYSHKANGQHEISFSVADTEVTSSISINSSEVPEVTQSENVGSSSQASSSDKAN
MLQEYSKFLQQALDRTSQNDAYLNSPSLNFVTDNQTLPNQPAFSSIDKQVYATMPINSFR
SGMNS*665PLRTTPDKSHFGLIVGDSQHSFPFSGDETNHASATSTQDFLDQVTSQKKAEAQPV
HQAYQMSSFEQPFRAPYHGSRAGIATQFSTANGQVNLRGPGTSAEFPEFPLVNVNDNRAG
MTSS*784PDATTGQTFG
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Predicted Disorder Regions | 49-67, 570-622, 716-734, 781-794 |
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DisProt Annotation | |
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TM Helix Prediction | no TM helices |
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Significance of PTMs | Phosphorylated by ERK at Ser306 and this results in ZNF148 binding to FOX1 which furthur facilitates Histone H3 acetylation and FOXM1-mediated Snail transcription and promotes cell invasion and tumor growth.Sumoylated by SUMO2. Desumoylated by SENP3, resulting in the stimulation of transcription of its target genes. |
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Additional Comments | Downregulation of ZNF148 drives the formation of a muscle phenotype with rapid expression of myosin heavy chain, even in proliferative conditions. |
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Bibliography | 1.Gao X, Ma C, Sun X, Zhao Q, Fang Y, Jiang Y, Shen K, Shen X. Upregulation of ZNF148 in SDHB-deficient gastrointestinal stromal tumor potentiates Forkhead box M1-mediated transcription and promotes tumor cell invasion. Cancer Sci. 2020 Apr;111(4):1266-1278. doi: 10.1111/cas.14348. Epub 2020 Mar 16. PMID: 32060966; PMCID: PMC7156819. |