Search by BoMiProt ID - Bomi10646

Primary Information

BoMiProt ID Bomi10646
Protein Name YrdC domain-containing protein, mitochondrial
Organism Bos taurus
Uniprot IDQ0VC80
Milk FractionWhey
Ref Sequence ID NP_001069018.1
Aminoacid Length 276
Molecular Weight 28893
FASTA Sequence Download
Gene Name YRDC
Gene ID 512062
Protein Existence Status reviewed

Secondary Information

Protein Function  involved in the formation of threonylcarbamoyladenosine in transfer ribonucleic acid
Biochemical Properties single domain.The protein contains a sua5-yciO-yrdC domain,a GTP-binding elongation factors signature (residues 229–241), and a leucine zipper pattern (residues 259–279).Leucine zipper pattern is related to protein dimerization and nucleic acid binding.YrdC binds preferentially to double-stranded RNA.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 1-5, 22-60
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1.Chen J, Ji C, Gu S, Zhao E, Dai J, Huang L, Qian J, Ying K, Xie Y, Mao Y. Isolation and identification of a novel cDNA that encodes human yrdC protein. J Hum Genet. 2003;48(4):164-9. doi: 10.1007/s10038-002-0001-3. Epub 2003 Mar 1. PMID: 12730717.2.Shen H, Zheng E, Yang Z, Yang M, Xu X, Zhou Y, Ni J, Li R, Zhao G. YRDC is upregulated in non-small cell lung cancer and promotes cell proliferation by decreasing cell apoptosis. Oncol Lett. 2020 Jul;20(1):43-52. doi: 10.3892/ol.2020.11560. Epub 2020 Apr 21. PMID: 32565932; PMCID: PMC7285791.