Primary Information |
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| BoMiProt ID | Bomi10598 |
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| Protein Name | WD repeat-containing protein 44/Rab11-binding protein/Rabphilin-11 |
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| Organism | Bos taurus |
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| Uniprot ID | Q9XSC3 |
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| Milk Fraction | Whey |
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| Aminoacid Length | 912 |
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| Molecular Weight | 101293 |
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| FASTA Sequence |
Download |
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| Gene Name | WDR44/RAB11BP |
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| Gene ID | 286825 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Rab11a small G protein (Rab11p) is implicated in vesicle trafficking, especially vesicle recycling. |
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| Biochemical Properties | The Rab family small G proteins have two interconvertible forms, the GDP-bound inactive and GTP-bound active forms. The conversion of the GDP-bound form to the GTP-bound form is regulated by two types of upstream regulators, GEPs and GDIs. The reverse conversion is regulated by GTPaseactivating proteins. Each Rab family member appears to have its specific GEP and GTPase-activating protein, whereas GDIs are active on all the Rab family members. |
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| PTMs | Acetylation at Lys,Phosphorylation at Ser/Thr |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q9XSC3|WDR44_BOVIN WD repeat-containing protein 44 OS=Bos taurus OX=9913 GN=WDR44 PE=1 SV=1
MAS*3ESDTEEFFDAPEDVHLEGGDPIGYPGKVGISALKETENSAYKVGNES*50TVQELKQDVS
KKIIES*66IIEES*71QKVIQLEDDS*81LDSKGKGQSDQATAS*96PVTAGTELSNIPGLLAIDQVLQED
SQKAES*126QDVSEETELESKQCFPSDDTCEKPVDETTKLT*158EISSTAQLNVPETVTEVLNKEE
VEVKESDVLESASSHSLSTKDFAVVEEVAPAKPPRQLT*218PEPDIVASTKKPVPARPPPPAN
FPPPRPPPPSRPAPPPRKKKS*261ELEFEALKT*270PDLDVPKENITSDTLLTTNMASESTVKDSQ
PSLDLASATSGDKIVTAQENGKAPDGQTIAGEVMGPQRPRS*341NS*343GRELT*348DEEILASVMIKN
LDTGEEIPLSLAEEKLPTGINPLTLHIMRRTKEYVSNDAAQS*402DDEEKLQSQQTDTDGGRL
KQKTTQLKKFLGKSVKRAKHLAEEYGERAVNKVKSVRDEVFHTDQDDPS*469S*470S*471DDEGMPY*478TRPVKFKAAHGFKGPYDFDQIKVVQDLSGEHMGAVWTMKFSHCGRLLASAGQDNVVRIWALK
NAFDYFNNMRMKYNTEGRVS*560PSPS*564QESLNSSKSDTDTGVCSGTDEDPDDKNAPFRQRPFC
KYKGHTADLLDLSWSKNYFLLSSSMDKTVRLWHISRRECLCCFQHIDFVTAIAFHPRDDR
YFLSGSLDGKLRLWNIPDKKVALWNEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYDT
EHLKYHTQIHVRSTRGRNKVGRKITGIEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYK
GYVNSSSQIKASFSHDFNYLVSGSEDKYVYIWSTYHDLSKFTSVRRDRNDFWEGIKAHNA
VVTSAIFAPNPSLMLSLDVQSEKSEGNEKGEDAEVLETMPSGIMKTDNTEVLLSADFTGA
IKVFINKRKNLS
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| Predicted Disorder Regions | 1-26, 44-46, 64-206, 249-253, 293-344 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | Overexpression of the C-terminal fragment of rabphilin-11 (aa 607-730), lacking the GTP-Rab11 binding domain, in HeLa cells reduced accumulation of transferrin at perinuclear regions and cell migration. |
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| Bibliography | 1.Mammoto A, Ohtsuka T, Hotta I, Sasaki T, Takai Y. Rab11BP/Rabphilin-11, a downstream target of rab11 small G protein implicated in vesicle recycling. J Biol Chem. 1999 Sep 3;274(36):25517-24. doi: 10.1074/jbc.274.36.25517. PMID: 10464283. 2.Mammoto A, Sasaki T, Kim Y, Takai Y. Physical and functional interaction of rabphilin-11 with mammalian Sec13 protein. Implication in vesicle trafficking. J Biol Chem. 2000 May 5;275(18):13167-70. doi: 10.1074/jbc.c000096200. PMID: 10747849. 3.. Takai, Y., Sasaki, T., Shirataki, H., and Nakanishi, H. (1996) Genes Cells 1,615–632. 4. Novick, P., and Zerial, M. (1997) Curr. Opin. Cell Biol. 9, 496–504. |
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