Primary Information |
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| BoMiProt ID | Bomi10596 |
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| Protein Name | WD repeat-containing protein 1 |
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| Organism | Bos taurus |
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| Uniprot ID | Q2KJH4 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001039811.1 |
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| Aminoacid Length | 606 |
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| Molecular Weight | 66258 |
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| FASTA Sequence |
Download |
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| Gene Name | WDR1 |
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| Gene ID | 533223 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | WD repeat-containing protein 1 maintains β-Catenin activity to promote pancreatic cancer aggressiveness. |
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| Biochemical Properties | WDR1 (WD-repeat domain 1) is a major cofactor of the actin depolymerizing factor (ADF)/cofilin, strongly accelerating ADF/cofilin-mediated actin disassembly. |
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| PTMs | Acetylation at Lys and Phosphorylation at Tyr |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q2KJH4|WDR1_BOVIN WD repeat-containing protein 1 OS=Bos taurus OX=9913 GN=WDR1 PE=2 SV=3
MPYEIKKVFASLPQVERGVSKIVGGDPKGNSFLYTNGKCVILRNIDNPAIADIYTEHAHQ
VVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVV
GEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLVTGSDDNCAAFFEGPPFK
FKFTISDHGRFVNCVRFSPDGNRFATASADGQIFIYDGKTGEKVCALGGSKAHDGGIY*238AI
SWSPDSTHLLSASGDKTSKIWDVNVNSVVNTFTMGSNVLDQQLGCLWQKDHLLSISLSGY
INYLDKNNPSKPLRVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFA
GKGHTNQVSRMTVDEHGQLVSCSMDDTVRYTNLTLRDYSGQGVVKLDVQPKCLAVGPGGY
TVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGETVAVGGADGNVRLYSILGTTLK
DEGKLLEAKGPVTDLAFSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAW
SPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVK
EWTIAY
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Phosphorylated during mitosis,may leads to proper regulation of cell division. |
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| Additional Comments | WDR1 Promotes Cell Growth and Migration and Contributes to Malignant Phenotypes of Non-small Cell Lung Cancer through ADF/cofilin-mediated Actin Dynamics |
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| Bibliography | 1.Yuan B, Zhang R, Hu J, Liu Z, Yang C, Zhang T, Zhang C. WDR1 Promotes Cell Growth and Migration and Contributes to Malignant Phenotypes of Non-small Cell Lung Cancer through ADF/cofilin-mediated Actin Dynamics. Int J Biol Sci. 2018 Jun 8;14(9):1067-1080. doi: 10.7150/ijbs.23845. PMID: 29989053; PMCID: PMC6036740. 2.Li H, Liu X, Jiang S, Zhou X, Yao L, Di Y, Jiang Y, Gu J, Mao Y, Li J, Jin C, Yang P, Fu D. WD repeat-containing protein 1 maintains β-Catenin activity to promote pancreatic cancer aggressiveness. Br J Cancer. 2020 Sep;123(6):1012-1023. doi: 10.1038/s41416-020-0929-0. Epub 2020 Jun 30. PMID: 32601462; PMCID: PMC7492282. |
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