Primary Information |
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| BoMiProt ID | Bomi10563 |
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| Protein Name | WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 |
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| Organism | Bos taurus |
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| Uniprot ID | Q08E66 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001070353.1 |
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| Aminoacid Length | 574 |
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| Molecular Weight | 62994 |
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| FASTA Sequence |
Download |
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| Gene Name | WFIKKN2 |
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| Gene ID | 531979 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | an antimyostatic agent |
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| Biochemical Properties | WFIKKN2 has practically no affinity for the prodomain, its ability to inhibit the activity of latent myostatin preparations may be mediated only by its interaction with the growth factor domain. |
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| PTMs | Glycosylation at Aspn |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q08E66|WFKN2_BOVIN WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 OS=Bos taurus OX=9913 GN=WFIKKN2 PE=2 SV=1
MWALRGCRSGSRWGQGAALLLLLLGVPPRGLALPPLRYSHAGICPNDMNPNLWVDAQSTC
KRECETDQECETYEKCCPNVCGTKSCVAARYMDVKGKKGPVGMPKEATCDHFMCLQQGSE
CDIWDGQPVCKCRDRCEKEPSFTCASDGLTYYNRCYMDAEACSKGITLAVVTCRYHFTWP
NTSPSPPETTVHPTTAPPETPGLDATAPALLNHPAHQSVTVGETVSFLCDVVGRPRPEIT
WEKQLEDRENVVMRPNHVRGNVVVTNIAQLVIYNAQPQDAGIYTCTARNAAGVLRADFPL
SVVSGGQASATAESSPNGTALPAAECLKPPDSDDCGEEQTRWYFDAQANNCLTFTFGHCH
RNRNHFETYEACMLACMSGSLAMCSLPALQGPCKAYVPRWAYNSQTGQCQSFVYGGCEGN
GNNFESREDCEESCPFPRGNQRCRACKPRQKLVTSFCRSDFVILGRISELTEEPDSGRAL
VTVDEVLKDEKMGLKFLGQEPLEVTLLHMDWTCPCPN*517VTVGEAPLIIMGEVDGGMAVLRP
DSFVGASSTRRARKLREVMHKKTCDVLKDFPGLQ
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | WFIKKN1 may have greater potential as an antimyostatic agent than WFIKKN2. |
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| Bibliography | Szláma G, Trexler M, Patthy L. Latent myostatin has significant activity and this activity is controlled more efficiently by WFIKKN1 than by WFIKKN2. FEBS J. 2013 Aug;280(16):3822-39. doi: 10.1111/febs.12377. Epub 2013 Jul 5. PMID: 23829672; PMCID: PMC3906830. |
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