Primary Information |
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BoMiProt ID | Bomi10563 |
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Protein Name | WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 |
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Organism | Bos taurus |
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Uniprot ID | Q08E66 |
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Milk Fraction | Whey |
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Ref Sequence ID | NP_001070353.1 |
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Aminoacid Length | 574 |
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Molecular Weight | 62994 |
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FASTA Sequence |
Download |
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Gene Name | WFIKKN2 |
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Gene ID | 531979 |
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Protein Existence Status | reviewed |
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Secondary Information |
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Protein Function | an antimyostatic agent |
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Biochemical Properties | WFIKKN2 has practically no affinity for the prodomain, its ability to inhibit the activity of latent myostatin preparations may be mediated only by its interaction with the growth factor domain. |
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PTMs | Glycosylation at Aspn |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q08E66|WFKN2_BOVIN WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 OS=Bos taurus OX=9913 GN=WFIKKN2 PE=2 SV=1
MWALRGCRSGSRWGQGAALLLLLLGVPPRGLALPPLRYSHAGICPNDMNPNLWVDAQSTC
KRECETDQECETYEKCCPNVCGTKSCVAARYMDVKGKKGPVGMPKEATCDHFMCLQQGSE
CDIWDGQPVCKCRDRCEKEPSFTCASDGLTYYNRCYMDAEACSKGITLAVVTCRYHFTWP
NTSPSPPETTVHPTTAPPETPGLDATAPALLNHPAHQSVTVGETVSFLCDVVGRPRPEIT
WEKQLEDRENVVMRPNHVRGNVVVTNIAQLVIYNAQPQDAGIYTCTARNAAGVLRADFPL
SVVSGGQASATAESSPNGTALPAAECLKPPDSDDCGEEQTRWYFDAQANNCLTFTFGHCH
RNRNHFETYEACMLACMSGSLAMCSLPALQGPCKAYVPRWAYNSQTGQCQSFVYGGCEGN
GNNFESREDCEESCPFPRGNQRCRACKPRQKLVTSFCRSDFVILGRISELTEEPDSGRAL
VTVDEVLKDEKMGLKFLGQEPLEVTLLHMDWTCPCPN*517VTVGEAPLIIMGEVDGGMAVLRP
DSFVGASSTRRARKLREVMHKKTCDVLKDFPGLQ
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Predicted Disorder Regions | NA |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Additional Comments | WFIKKN1 may have greater potential as an antimyostatic agent than WFIKKN2. |
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Bibliography | Szláma G, Trexler M, Patthy L. Latent myostatin has significant activity and this activity is controlled more efficiently by WFIKKN1 than by WFIKKN2. FEBS J. 2013 Aug;280(16):3822-39. doi: 10.1111/febs.12377. Epub 2013 Jul 5. PMID: 23829672; PMCID: PMC3906830. |