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Primary Information | |
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| BoMiProt ID | Bomi10544 |
| Protein Name | V-type proton ATPase subunit d 1/32 kDa accessory protein/V-ATPase 40 kDa accessory protein |
| Organism | Bos taurus |
| Uniprot ID | P61420 |
| Milk Fraction | Whey |
| Ref Sequence ID | NP_776930.1 |
| Aminoacid Length | 351 |
| Molecular Weight | 40329 |
| FASTA Sequence | Download |
| Gene Name | ATP6V0D1 |
| Gene ID | 282148 |
| Protein Existence Status | Reviewed |
Secondary Information | |
| Presence in other biological fluids/tissue/cells | brain |
| Protein Function | p39, the primary activator for cyclin-dependent kinase 5 (Cdk5) in oligodendroglia, is essential for oligodendroglia differentiation and myelin repair |
| PTMs | Phosphorylation at Ser/Tyr |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | >sp|P61420|VA0D1_BOVIN V-type proton ATPase subunit d 1 OS=Bos taurus OX=9913 GN=ATP6V0D1 PE=1 SV=1 MSFFPELYFNVDNGYLEGLVRGLKAGVLSQADYLNLVQCETLEDLKLHLQSTDYGNFLAN EASPLTVSVIDDRLKEKMVVEFRHMRNHAYEPLASFLDFITYSYMIDNVILLITGTLHQR SIAELVPKCHPLGSFEQMEAVNIAQTPAELYNAILVDTPLAAFFQDCISEQDLDEMNIEI IRNTLYKAYLESFYKFCTLLGGTTADAMCPILEFEADRRAFIITINSFGTELSKEDRAKL FPHCGRLYPEGLAQLARADDYEQVKNVADY*270YPEYKLLFEGAGS*283NPGDKTLEDRFFEHEVK LNKLAFLNQFHFGVFYAFVKLKEQECRNIVWIAECIAQRHRAKIDNYIPIF |
| CATH | Matched CATH superfamily n/a |
| Predicted Disorder Regions | NA |
| DisProt Annotation | |
| TM Helix Prediction | No TM helices |
| PDB ID | 6XBW, 6XBY, 7KHR, |
| Additional Comments | The loss of p39 attenuates overall Cdk5 activity in neurons and preferentially affects phosphorylation of specific Cdk5 targets, leading to aberrant axonal growth and impaired dendritic spine and synapse formation. |
| Bibliography | 1.Bankston AN, Li W, Zhang H, Ku L, Liu G, Papa F, Zhao L, Bibb JA, Cambi F, Tiwari-Woodruff SK, Feng Y. p39, the primary activator for cyclin-dependent kinase 5 (Cdk5) in oligodendroglia, is essential for oligodendroglia differentiation and myelin repair. J Biol Chem. 2013 Jun 21;288(25):18047-57. doi: 10.1074/jbc.M113.453688. Epub 2013 May 3. PMID: 23645679; PMCID: PMC3689949. 2. |