Search by BoMiProt ID - Bomi10544


Primary Information

BoMiProt ID Bomi10544
Protein Name V-type proton ATPase subunit d 1/32 kDa accessory protein/V-ATPase 40 kDa accessory protein
Organism Bos taurus
Uniprot IDP61420
Milk FractionWhey
Ref Sequence ID NP_776930.1
Aminoacid Length 351
Molecular Weight 40329
FASTA Sequence Download
Gene Name ATP6V0D1
Gene ID 282148
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells brain
Protein Function p39, the primary activator for cyclin-dependent kinase 5 (Cdk5) in oligodendroglia, is essential for oligodendroglia differentiation and myelin repair
PTMs Phosphorylation at Ser/Tyr
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|P61420|VA0D1_BOVIN V-type proton ATPase subunit d 1 OS=Bos taurus OX=9913 GN=ATP6V0D1 PE=1 SV=1 MSFFPELYFNVDNGYLEGLVRGLKAGVLSQADYLNLVQCETLEDLKLHLQSTDYGNFLAN EASPLTVSVIDDRLKEKMVVEFRHMRNHAYEPLASFLDFITYSYMIDNVILLITGTLHQR SIAELVPKCHPLGSFEQMEAVNIAQTPAELYNAILVDTPLAAFFQDCISEQDLDEMNIEI IRNTLYKAYLESFYKFCTLLGGTTADAMCPILEFEADRRAFIITINSFGTELSKEDRAKL FPHCGRLYPEGLAQLARADDYEQVKNVADY*270YPEYKLLFEGAGS*283NPGDKTLEDRFFEHEVK LNKLAFLNQFHFGVFYAFVKLKEQECRNIVWIAECIAQRHRAKIDNYIPIF
CATH Matched CATH superfamily
n/a
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
PDB ID 6XBW, 6XBY, 7KHR,
Additional Comments The loss of p39 attenuates overall Cdk5 activity in neurons and preferentially affects phosphorylation of specific Cdk5 targets, leading to aberrant axonal growth and impaired dendritic spine and synapse formation.
Bibliography 1.Bankston AN, Li W, Zhang H, Ku L, Liu G, Papa F, Zhao L, Bibb JA, Cambi F, Tiwari-Woodruff SK, Feng Y. p39, the primary activator for cyclin-dependent kinase 5 (Cdk5) in oligodendroglia, is essential for oligodendroglia differentiation and myelin repair. J Biol Chem. 2013 Jun 21;288(25):18047-57. doi: 10.1074/jbc.M113.453688. Epub 2013 May 3. PMID: 23645679; PMCID: PMC3689949. 2.