Primary Information |
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| BoMiProt ID | Bomi10505 |
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| Protein Name | Voltage-dependent L-type calcium channel subunit beta-3/CAB3/Calcium channel voltage-dependent subunit beta 3 |
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| Organism | Bos taurus |
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| Uniprot ID | Q9MZL3 |
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| Milk Fraction | whey |
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| Ref Sequence ID | NP_776934.1 |
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| Aminoacid Length | 484 |
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| Molecular Weight | 54569 |
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| FASTA Sequence |
Download |
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| Gene Name | CACNB3 |
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| Gene ID | 282160 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | It increases peak calcium current of CACNA1B and CACNA1B and shifts the voltage dependencies of channel activation and inactivation |
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| Biochemical Properties | Interacts with CBARP; prevents the interaction of CACNB3 with the alpha subunit CACNA1C thereby negatively regulating the activity of the corresponding calcium channel |
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| PTMs | Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q9MZL3|CACB3_BOVIN Voltage-dependent L-type calcium channel subunit beta-3 OS=Bos taurus OX=9913 GN=CACNB3 PE=2 SV=2
MYDDSYVPGFEDSEAGSADSYTSRPSLDSDVSLEEDRESARREVESQAQQQLERAKHKPV
AFAVRTNVSYCGVLDEECPVQGSGVNFEAKDFLHIKEKYSNDWWIGRLVKEGGDIAFIPS
PQRLESIRLKQEQKARRSGNPSSLSDIGSRRS*152PPPSLAKQKQKQAEHIPPYDVVPSMRPV
VLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADLSLAKRSVLNNPGKRTIIER
SSARSSIAEVQSEIERIFELAKSLQLVVLDADTINHPAQLAKTSLAPIIVFVKVSSPKVL
QRLIRSRGKSQMKHLTVQMMAYDKLVQCPPESFDVILDENQLEDACEHLAEYLEVYWRAT
HHPAPGPGLLGPPSAIPGLQNQQLLGERGEEHS*393PLERDSLMPSDEASESSRQAWTGSSQR
SSRHLEEDYADAYHDLYQPHRQHTSGLPSANGHDPQDRLLAQDSEHNHNERNWQRNRPWP
KDSY
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| Predicted Disorder Regions | 1-56, 132-172, 307-317, 363-377, 387-484 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Cahill, A. L., Hurley, J. H., & Fox, A. P. (2000). Coexpression of cloned alpha(1B), beta(2a), and alpha(2)/delta subunits produces non-inactivating calcium currents similar to those found in bovine chromaffin cells. The Journal of neuroscience : the official journal of the Society for Neuroscience, 20(5), 1685–1693. https://doi.org/10.1523/JNEUROSCI.20-05-01685.2000 |
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