Primary Information |
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| BoMiProt ID | Bomi10483 |
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| Protein Name | Vesicular glutamate transporter 1/Solute carrier family 17 member 7 |
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| Organism | Bos taurus |
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| Uniprot ID | A4FV52 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001091515.1 |
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| Aminoacid Length | 560 |
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| Molecular Weight | 61651 |
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| FASTA Sequence |
Download |
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| Gene Name | SLC17A7/VGLUT1 |
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| Gene ID | 518849 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | VGLUT1-mediated glutamate release and membrane GluA1 activation may play a critical role in the rapid-acting antidepressant-like effects of scopolamine in mice. |
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| PTMs | Phosphorylation at Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A4FV52|VGLU1_BOVIN Vesicular glutamate transporter 1 OS=Bos taurus OX=9913 GN=SLC17A7 PE=2 SV=1
MEFRQEEFRKLAGRALGKLHRLLEKRQEGAETLELSADGRPVTTQTRDPPVVDCTCFGLP
RRYIIAIMSGLGFCISFGIRCNLGVAIVSMVNNSTTHRGGHVVMQKAQFNWDPETVGLIH
GSFFWGYIVTQIPGGFICQKFAANRVFGFAIVATSTLNMLIPSAARVHYGCVIFVRILQG
LVEGVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVLVQYSGWSSVFYV
YGSFGIFWYLFWLLVSYESPALHPSISEEERKYIEDAIGESAKLMNPVTKFNTPWRRFFT
SMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGQ
IADFLRSRRIMSTTNVRKLMNCGGFGMEATLLLVVGYSHSKGVAISFLVLAVGFSGFAIS
GFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKHKTREEWQYVFLIASLVHY
GGVIFYGVFASGEKQPWAEPEEMS*504EEKCGFVGHDQLAGSDESEMEDEAEPPGAPPAPPPS
YGATHSTVQPPRPPPPVRDY
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| Predicted Disorder Regions | 497-560 |
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| DisProt Annotation | |
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| TM Helix Prediction | 10TMHs; (65-87),(115-137),(206-228),(237-255),(299-321),(340-362),(380-398),(402-424),(437-459),(468-490) |
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| Additional Comments | VGLUT1 knockdown alleviated the rapid antidepressant-like actions of scopolamine and the effects of scopolamine on membrane GluA1-mediated BDNF, VGF and BICC1 changes.VGLUT1 is primarily expressed in the hippocampus and
cerebellar cortex and plays a critical role in the glutamate release and efficacy of
glutamatergic transmission in the CNS |
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