Primary Information |
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| BoMiProt ID | Bomi10471 |
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| Protein Name | Very long-chain specific acyl-CoA dehydrogenase, mitochondrial |
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| Organism | Bos taurus |
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| Uniprot ID | P48818 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_776919.1 |
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| Aminoacid Length | 655 |
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| Molecular Weight | 70649 |
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| FASTA Sequence |
Download |
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| Gene Name | ACADVL |
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| Gene ID | 282130 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | role in fatty acid oxidation. initial rate-limiting step of β-oxidation of long chain fatty acids. |
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| Significance in milk | mitochondrial lipid metabolism |
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| PTMs | Acetylation, Phosphoprotein, S-nitrosylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|P48818|ACADV_BOVIN Very long-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Bos taurus OX=9913 GN=ACADVL PE=2 SV=3
MRAARMAQSTGRQLLRLRGVSSWPGELLGQPRPGPARRPYASGVAQAAVDQSDSQPSEAS
TREKRANSVSKSFAVGTFKGQLTTDQVFPYPSVLNEDQTQFLKELVGPVTRFFEEVNDAA
KNDMLERVEETTMQGLKELGAFGLQVPNELGGVGLCNTQYARLVEIVGMYDLGVGIVLGA
HQSIGFKGILLFGTKAQKEKYLPKLASGETIAAFCLTEPSSGSDAASIRSSAVPSPCGKY
YTLNGSKIWISNGGLADIFTVFAKTPVTDTATGAVKEKITAFVVERSFGGVTHGPPEKKM
GIKASNTAEVYFDGVRVPAENVLGEVGGGFKVAMHILNNGRFGMAAALAGTMKGIIAKAV
DHAANRTQFGEKIHNFGLIQEKLARMAMLQYVTESMAYMVSANMDQGSTDFQIEAAISKI
FGSEAAWKVTDECIQIMGGMGFMKEPGVERVLRDLRIFRIFEGTNDILRLFVALQGCMDK
GKELSGLGNALKNPFGNAGLLLGEAGKQLRRRAGLGS*517GLSLS*522GIVHQELSRSGELAVQAL
EQFATVVEAKLIKHKKDIINEQFLLQRLADSAIDLYAMVVVLSRASRSLSEGHPTAQHEK
MLCDSWCIEAAARIRENMTALQSDPQQQELFRNFKSISKALVERGGVVTSNPLGF
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| Predicted Disorder Regions | 1 disordered segment; (1-65) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Miller MJ, Burrage LC, Gibson JB, Strenk ME, Lose EJ, Bick DP, Elsea SH, Sutton VR, Sun Q, Graham BH, Craigen WJ, Zhang VW, Wong LJ. Recurrent ACADVL molecular findings in individuals with a positive newborn screen for very long chain acyl-coA dehydrogenase (VLCAD) deficiency in the United States. Mol Genet Metab. 2015 Nov;116(3):139-45. doi: 10.1016/j.ymgme.2015.08.011. Epub 2015 Sep 2. PMID: 26385305; PMCID: PMC4790081. |
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