Primary Information
BoMiProt ID	Bomi10429
Protein Name	Urocortin-3/Urocortin III/Ucn III
Organism	Bos taurus
Uniprot ID	Q1RMJ9
Milk Fraction	whey
Ref Sequence ID	NP_001069995.1
Aminoacid Length	166
Molecular Weight	17849
FASTA Sequence	Download
Gene Name	UCN3/SPC
Gene ID	751573
Protein Existence Status	Reviewed
Secondary Information
Protein Function	Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress
Biochemical Properties	The C-terminal sequence of both human and mouse Ucn III peptides contains a pair of basic residues, RK for the human and KK for the mouse, immediately preceded by a glycine, presumed to be involved in C-terminal amidation.
PTMs	Amydation
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	na
Predicted Disorder Regions	1-126, 144-166
DisProt Annotation
TM Helix Prediction	No TM helices
Bibliography	1.Lewis, K., Li, C., Perrin, M. H., Blount, A., Kunitake, K., Donaldson, C., Vaughan, J., Reyes, T. M., Gulyas, J., Fischer, W., Bilezikjian, L., Rivier, J., Sawchenko, P. E., & Vale, W. W. (2001). Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. Proceedings of the National Academy of Sciences of the United States of America, 98(13), 7570–7575. https://doi.org/10.1073/pnas.121165198 2.Zhang, X., Liu, Y., Qi, J., Tian, Z., Tang, N., Chen, D., & Li, Z. (2019). Progress in understanding the roles of Urocortin3 (UCN3) in the control of appetite from studies using animal models. Peptides, 121, 170124. https://doi.org/10.1016/j.peptides.2019.170124