Primary Information |
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| BoMiProt ID | Bomi10427 |
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| Protein Name | Uridine 5'-monophosphate synthase/OMPdecase |
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| Organism | Bos taurus |
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| Uniprot ID | P31754 |
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| Milk Fraction | Exosomes |
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| Ref Sequence ID | NP_803474.1 |
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| Aminoacid Length | 480 |
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| Molecular Weight | 52229 |
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| FASTA Sequence |
Download |
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| Gene Name | UMPS |
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| Gene ID | 281568 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | Orotate phosphoribosyltransferase (OPRT) is engaged in de novo pyrimidine synthesis. It catalyzes oronitine to uridine monophosphate (UMP), which is used for RNA synthesis. De novo pyrimidine synthesis has long been known to play an important role in providing DNA/RNA precursors for rapid proliferative activity of cancer cells. |
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| PTMs | Phosphorylation at Ser/Tyr,N-acetylation at Ala |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|P31754|UMPS_BOVIN Uridine 5'-monophosphate synthase OS=Bos taurus OX=9913 GN=UMPS PE=2 SV=1
MAAADALLGSLVTGLYDVQAFKFGNFVLKSGLSSPVY*37IDLRGIISRPSILNQVAEMLFQT
AENAEINFDTVCGVPYTALPLATIVCSTHEIPMLIRRKEKKDYGTKRLIEGAVNPGDTCL
IIEDVVSSGSSVWETAEVLQKEGLKVTDAVVLVDREQGGRDNLQARGIRLHSVCTLSTVL
CILEQQKKINAETVERVKRFIQENAFVAANPNDS*214LPSVKKEPKELSFGARAELPGTHPVA
AKLLRLMQKKETNLCLSADVSESRELLQLADALGSRICLLKIHVDILNDFTLDVMKELTT
LAKRHEFLIFEDRKFADIGNTVKKQYEGGVFKIASWADLVNAHAVPGSGVVKGLEEVGLP
LHRACLLVAEMSSAGTLATGSYTEAAVQMAEEHSEFVIGFISGSRVSMKPEFLHLTPGVQ
LEAGGDNLGQQYHSPQEVIGKRGSDIIIVGRGIIASANQLEAAKMYRKAAWEAYLSRLAV
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | 1.Hozumi Y, Tanaka T, Nakano T, Matsui H, Nasu T, Koike S, Kakehata S, Ito T, Goto K. Orotate phosphoribosyltransferase localizes to the Golgi complex and its expression levels affect the sensitivity to anti-cancer drug 5-fluorouracil. Biomed Res. 2015;36(6):403-9. doi: 10.2220/biomedres.36.403. PMID: 26700594. 2. |
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